Abstract

The overall goal of the Pilot and Feasibility Study Program is to enrich the scientific base of the DERC at Joslin as well as to enhance research on types 1 and 2 diabetes and their complications more generally. This goal can be achieved through bringing in talented new investigators or by taking up promising new experimental strategies or methods. Therefore, the program has traditionally provided support to three types of researchers: a. beginning investigators in the diabetes field who have not yet received substantial NIH funding;tx seasoned investigators in the diabetes field who wish to strike out in a novel direction;and a investigators from other fields embarking on a diabetes-related project for the first time.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK036836-24
Application #
8060625
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
24
Fiscal Year
2010
Total Cost
$324,928
Indirect Cost

  Institution

Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Srinivasan, Shylaja; Kaur, Varinderpal; Chamarthi, Bindu et al. (2018) TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH). Diabetes Care 41:554-561
Goldford, Joshua E; Lu, Nanxi; Baji?, Djordje et al. (2018) Emergent simplicity in microbial community assembly. Science 361:469-474
Soto, Marion; Orliaguet, Lucie; Reyzer, Michelle L et al. (2018) Pyruvate induces torpor in obese mice. Proc Natl Acad Sci U S A 115:810-815
Karst, Sonja G; Lammer, Jan; Radwan, Salma H et al. (2018) Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy. Int J Endocrinol 2018:7492946
Espeland, Mark A; Carmichael, Owen; Hayden, Kathleen et al. (2018) Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci 73:484-491
Kim, Youngjo; Bayona, Princess Wendy; Kim, Miri et al. (2018) Macrophage Lamin A/C Regulates Inflammation and the Development of Obesity-Induced Insulin Resistance. Front Immunol 9:696
Aguayo-Mazzucato, Cristina; Bonner-Weir, Susan (2018) Pancreatic ? Cell Regeneration as a Possible Therapy for Diabetes. Cell Metab 27:57-67
Mulla, Christopher M; Middelbeek, Roeland J W; Patti, Mary-Elizabeth (2018) Mechanisms of weight loss and improved metabolism following bariatric surgery. Ann N Y Acad Sci 1411:53-64
Skupien, Jan; Smiles, Adam M; Valo, Erkka et al. (2018) Variations in Risk of End-Stage Renal Disease and Risk of Mortality in an International Study of Patients With Type 1 Diabetes and Advanced Nephropathy. Diabetes Care :
Laffel, L (2018) Lost in transition: finding a path forward for young adults with Type 1 diabetes. Diabet Med 35:1061-1062

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