The purpose of the Advanced Microscopy Core is to have sophisticated morphological techniques readily available to all investigators at Joslin. The Core provides a wide range of service covering the broad categories: performing specific morphological procedures, providing access to equipment and reagents, and giving advice, training and interpretation. There are four main components to this core: Electron Microscopy (EM), Confocal, Histology and Laser Capture Dissection (LCM) facilities. Each has been serving Joslin researchers by providing timely, quality morphological backup for their research needs with personalized service. The components run differently: the plastic embedding and electron microscope work is done by the Core Manager;the Core Histology Technician takes fixed/frozen tissue and returns slides (H&E and unstained);both the Confocal microscope and Laser Capture Microscope are used directly by the individual investigators with the Core training new users, providing maintenance of the microscopes, and troubleshooting problems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK036836-25
Application #
8249911
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
2012-08-31
Budget Start
2011-04-01
Budget End
2013-03-31
Support Year
25
Fiscal Year
2011
Total Cost
$190,876
Indirect Cost
Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215
Panduro, Marisella; Benoist, Christophe; Mathis, Diane (2018) Treg cells limit IFN-? production to control macrophage accrual and phenotype during skeletal muscle regeneration. Proc Natl Acad Sci U S A 115:E2585-E2593
McGill, Dayna E; Volkening, Lisa K; Pober, David M et al. (2018) Depressive Symptoms at Critical Times in Youth With Type 1 Diabetes: Following Type 1 Diabetes Diagnosis and Insulin Pump Initiation. J Adolesc Health 62:219-225
Katz, Michelle L; Guo, Zijing; Laffel, Lori M (2018) Management of Hypertension and High Low-Density Lipoprotein in Pediatric Type 1 Diabetes. J Pediatr 197:140-146.e12
Stanford, Kristin I; Goodyear, Laurie J (2018) Muscle-Adipose Tissue Cross Talk. Cold Spring Harb Perspect Med 8:
Altindis, Emrah; Cai, Weikang; Sakaguchi, Masaji et al. (2018) Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions. Proc Natl Acad Sci U S A 115:2461-2466
Yoon, Sujung; Kim, Jungyoon; Musen, Gail et al. (2018) Prefronto-temporal white matter microstructural alterations 20?years after the diagnosis of type 1 diabetes mellitus. Pediatr Diabetes 19:478-485
Silva, Paolo S; Gupta, Aditi; Ajlan, Radwan S et al. (2018) Ultrawide field scanning laser ophthalmoscopy imaging of lipemia retinalis. Acta Ophthalmol 96:e643-e646
Ewald, Collin Yvès; Castillo-Quan, Jorge Iván; Blackwell, T Keith (2018) Untangling Longevity, Dauer, and Healthspan in Caenorhabditis elegans Insulin/IGF-1-Signalling. Gerontology 64:96-104
Viana-Huete, Vanesa; Guillén, Carlos; García, Gema et al. (2018) Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity. Endocrinology 159:323-340
Peterson, Claire M; Young-Hyman, Deborah; Fischer, Sarah et al. (2018) Examination of Psychosocial and Physiological Risk for Bulimic Symptoms in Youth With Type 1 Diabetes Transitioning to an Insulin Pump: A Pilot Study. J Pediatr Psychol 43:83-93

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