The CURE: DDRCC's existence provides an important foundation for building a critical mass of investigators whose creativity and productivity are enhanced by the sharing of techniques, resources, and ideas, and by the enrichment activities that facilitate ongoing scientific exchange. Funding of this renewal application will ensure that the CURE: DDRCC can continue to provide the resources and environment required to foster significant multidisciplinary collaborations among established investigators. The CURE: DDRCC also will continue to provide an optimal milieu in which trainees can advance through their postdoctoral training period to establishing independent programs that lead to obtaining peer-reviewed grant support and faculty positions in digestive diseases-related research. The Biomedical Research Cores, the Pilot and Feasibility Study program and assistance provided by the Administrative Core are especially valuable to these young scientists. By its very definition, a multidisciplinary research center brings together the activities of a variety of scientists, each with individual projects, ideas and scientific approaches. In order for these diverse elements to be integrated into a productive research unit, a Director and an Administrative Core must have the ability to develop mission, goals, and strategies that will unify the center into a cohesive, cost effective whole that is ultimately greater than its individual components. The leadership and the Administrative Core that have been assembled at CURE for this Digestive Diseases Research Core Center application have proven their capability in accomplishing the goals set forth in the previous paragraph. The Administrative Core is an integral part of every Center segment and its activities are inten/voven in all facets of the CURE: DDRCC. Under the guidance of the CURE: DDRCC Director, J. Enrique Rozengurt, Co-Director, Emeran Mayer, and Associate Directors Dennis Jensen, Charalabos Pothoulakis, Catia Sternini, Yvette Tache, and Ernest Wright, the Administrative Core is able to accomplish effectively the elements of integration, unification, communication and information exchange that are absolutely necessary for accomplishing the specific aims of this Center.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK041301-25
Application #
8578088
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
25
Fiscal Year
2014
Total Cost
$470,684
Indirect Cost
$106,758
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Chen, Wenling; Taché, Yvette; Marvizón, Juan Carlos (2018) Corticotropin-Releasing Factor in the Brain and Blocking Spinal Descending Signals Induce Hyperalgesia in the Latent Sensitization Model of Chronic Pain. Neuroscience 381:149-158
Gupta, Arpana; Woodworth, Davis C; Ellingson, Benjamin M et al. (2018) Disease-Related Microstructural Differences in the Brain in Women With Provoked Vestibulodynia. J Pain 19:528.e1-528.e15
Marcus, Elizabeth A; Sachs, George; Scott, David R (2018) Acid-regulated gene expression of Helicobacter pylori: Insight into acid protection and gastric colonization. Helicobacter 23:e12490
Ziyad, Safiyyah; Riordan, Jesse D; Cavanaugh, Ann M et al. (2018) A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis. Cell Rep 22:1211-1224
Biczo, Gyorgy; Vegh, Eszter T; Shalbueva, Natalia et al. (2018) Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models. Gastroenterology 154:689-703
Salehi, Sahar; Sosa, Rebecca A; Jin, Yi-Ping et al. (2018) Outside-in HLA class I signaling regulates ICAM-1 clustering and endothelial cell-monocyte interactions via mTOR in transplant antibody-mediated rejection. Am J Transplant 18:1096-1109
Jin, Yi-Ping; Valenzuela, Nicole M; Zhang, Xiaohai et al. (2018) HLA Class II-Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection. J Immunol 200:2372-2390
Fulcher, Jennifer A; Shoptaw, Steven; Makgoeng, Solomon B et al. (2018) Brief Report: Recent Methamphetamine Use Is Associated With Increased Rectal Mucosal Inflammatory Cytokines, Regardless of HIV-1 Serostatus. J Acquir Immune Defic Syndr 78:119-123
Wang, Bo; Rong, Xin; Palladino, Elisa N D et al. (2018) Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis. Cell Stem Cell 22:206-220.e4
Gupta, Arpana; Mayer, Emeran A; Labus, Jennifer S et al. (2018) Sex Commonalities and Differences in Obesity-Related Alterations in Intrinsic Brain Activity and Connectivity. Obesity (Silver Spring) 26:340-350

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