The overall goals of the CURE: DDRCC Human Studies Core (HSC) are to provide leadership and an infrastructure to enhance clinical and translational research in digestive diseases. This is implemented by providing specific services to CURE investigators with research grants, their trainees, and collaborators. The specific goals of the Human Studies Core are to provide CURE:DDRCC members, trainees, and their collaborators with access to: 1) expert researchers and their staff in clinical, endoscopic, translational, and outcomes research for assistance and advice about cognitive, technical and procedural aspects of these types of gastrointestinal (Gl) research; 2) facilitate utilization of fully equipped and networked endoscopy medical procedure units (MPU's) for GI clinical, physiologic and translational research studies; 3) teaching clinical research techniques and consultation about study design, data management, software options, statistical analysis, and routine outcomes of prospective randomized controlled studies of large multicenter or cooperative trials for diagnosis or treatments in Gl disorders; 4) expertise, utilization, and collaboration with PI'S and their research staff who maintain tissue, cyst fluid, sera and other bio-specimens and HIPAA compliant databases of clinical patients with selected Gl diseases (e.g. obesity, Gl hemorrhage, small bowel disorders, pancreatic pre-cancerous conditions, Barrett's epithelium with and without dysplasia, Gl mucosal inflammatory diseases -AIDS or IBD - and neuroenteric or functional Gl diseases); and 5) expertise and utilization of specialized equipment for Gl intra-luminal studies in collaboration with experts, including deep enteroscopy and capsule endoscopy for small bowel. There are 18 investigators who will utilize these core services at UCLA and VA. This has been a unique and successful core that has provided services in the last 5 years to 20 funded users and 19 pre and post doctoral trainees. This core has facilitated their academic careers by enhancing collaborative research, providing services to develop research results that contributed to funding of several important federal grants, and contributed to significant research publications related to Gl disorders.

Public Health Relevance

Our goals are to improve understanding, knowledge, and treatment of Gl disorders in a cost-effective and collaborative approach. Using patients and human samples to study pathogenesis and treatments increases the relevance to human diseases. The Human Studies Core space, equipment, expertise, and personnel required to provide these services are expensive but are shared for collaborative research with clinical, outcomes and translational researchers and their trainees in a cost-effective way.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK041301-29
Application #
9392153
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2017-12-01
Budget End
2018-11-30
Support Year
29
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Gupta, Arpana; Woodworth, Davis C; Ellingson, Benjamin M et al. (2018) Disease-Related Microstructural Differences in the Brain in Women With Provoked Vestibulodynia. J Pain 19:528.e1-528.e15
Chen, Wenling; Taché, Yvette; Marvizón, Juan Carlos (2018) Corticotropin-Releasing Factor in the Brain and Blocking Spinal Descending Signals Induce Hyperalgesia in the Latent Sensitization Model of Chronic Pain. Neuroscience 381:149-158
Ziyad, Safiyyah; Riordan, Jesse D; Cavanaugh, Ann M et al. (2018) A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis. Cell Rep 22:1211-1224
Marcus, Elizabeth A; Sachs, George; Scott, David R (2018) Acid-regulated gene expression of Helicobacter pylori: Insight into acid protection and gastric colonization. Helicobacter 23:e12490
Salehi, Sahar; Sosa, Rebecca A; Jin, Yi-Ping et al. (2018) Outside-in HLA class I signaling regulates ICAM-1 clustering and endothelial cell-monocyte interactions via mTOR in transplant antibody-mediated rejection. Am J Transplant 18:1096-1109
Biczo, Gyorgy; Vegh, Eszter T; Shalbueva, Natalia et al. (2018) Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models. Gastroenterology 154:689-703
Fulcher, Jennifer A; Shoptaw, Steven; Makgoeng, Solomon B et al. (2018) Brief Report: Recent Methamphetamine Use Is Associated With Increased Rectal Mucosal Inflammatory Cytokines, Regardless of HIV-1 Serostatus. J Acquir Immune Defic Syndr 78:119-123
Jin, Yi-Ping; Valenzuela, Nicole M; Zhang, Xiaohai et al. (2018) HLA Class II-Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection. J Immunol 200:2372-2390
Gupta, Arpana; Mayer, Emeran A; Labus, Jennifer S et al. (2018) Sex Commonalities and Differences in Obesity-Related Alterations in Intrinsic Brain Activity and Connectivity. Obesity (Silver Spring) 26:340-350
Wang, Bo; Rong, Xin; Palladino, Elisa N D et al. (2018) Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis. Cell Stem Cell 22:206-220.e4

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