The Cell Biology Core of the DDRCC provides services vital to the study of the structure and function of? cells of the digestive systems in the context of normal physiology, immune/inflammatory conditions,? microbial interactions, and inflammatory bowel diseases. There are three major components: (1) Cell? Culture, (2) Structural Biology/Imaging, and (3) Cell physiology. The Core's services and facilities are? centralized under one administration to enhance efficiency, cost-effectiveness, and coordination of all? components. It has undergone yearly revisions in services and facilities of to meet the growing and changing? needs of Core users. The Administrative Director of the Cell Biology Core, Dr. Eugene Chang, oversees the? operations of all components and also serves as the Director of the Cell Culture component. Drs. Deborah? Nelson and Vytas Bindokas are the Directors of the Cell Physiology and Structural Biology/Imaging? components, respectively. Directors are responsible for ensuring proper scientific direction and efficient use? of services and facilities of their respective sections. This Core is the most heavily used by DDRCC members? because of the tremendous cost savings, relevance, and high quality of services and resources. The Cell? Culture component offers numerous epithelial and non-epithelial cell lines that are well characterized and? have properties that make them suitable models for many types of investigations of mucosal inflammation? and IBD. The Cell Physiology Component provides expertise and assistance for electrophysiological and? physiological measures in whole tissue and single cells. The Structural Biology/Imaging facility provides? high end, state-of-the-art services and facilities that are readily accessible by users and extremely cost-? effective. All Components offer training of new and established investigators unfamiliar with these? experimental approaches. The Core has successfully fostered multidisciplinary interactions and? collaborations by promoting active dialogue and exchange of ideas and information through sharing of? resources.?
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