The Tissue Engineering and Cell Models Core (TECM) enables DDRCC investigators to address key questions relating to causality and mechanisms by providing novel and vetted experimental models that can be customized to their needs. It was established 21 months ago, replacing the Genomics and Molecular Engineering (GME) Core of the DDRCC. The reorganization of the Core was a direct result of two sequential annual needs assessments indicating strong interest by the membership for more physiologically-relevant experimental models to study digestive health and diseases. The TECM has three major components: (1) A centralized repository and facility for established and primary gut-relevant cell lines, which was originally part of the host-microbe core, but moved to the TECM to centralize all cell and tissue experimental systems, (2) A tissue engineering component that includes customizing and developing intestinal organoid technologies for specific applications needed by DDRCC users, and (3) an experimental systems component that includes in vivo models (rodent microsurgery and C. elegans), ex vivo models, and live functional assays. Inherent to these services, the TECM provides training and education, opportunities for cost-savings through bulk purchases (serum, disposables, etc), and technical expertise that saves investigators time and insure high quality of services. The TECM is inextricably tied to the other DDRCC cores. The integrated Translational Research (ITR) and the Host-Microbe (HM) cores are essential for providing cells, tissues, and patient samples for establishing the experimental models. The Tissue and Cell Analysis (TCA) core provides investigators with the means to analyze data derived from the model systems. Thus, the TECM Core has had great impact in enabling DDRCC members to advance knowledge in the thematic areas fostered by the DDRCC which focus on the study of IBD, host-microbe interactions, mucosal immunology and inflammation. In the past year, it was used by 86% of the DDRCC membership and was used in 195 peer-reviewed publications or 65% of the total (306) DDRCC-acknowledged publications during this period. The TECM has promoted interaction, collaboration, cost-sharing, and efficient resources utilization, and, at the same time, has enhanced the capabilities of our investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK042086-30
Application #
9838212
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
30
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Wang, Yunwei; Lin, Fanfei; Zhu, Xiaorong et al. (2018) Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis. Am J Physiol Gastrointest Liver Physiol 314:G164-G178
Walker, Amy V; Gelb, Lev D; Barry, Grant E et al. (2018) Femtosecond laser desorption ionization mass spectrometry imaging and multivariate analysis of lipids in pancreatic tissue. Biointerphases 13:03B416
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Wang, Jingzhou; Bhatia, Arvin; Krugliak Cleveland, Noa et al. (2018) Rapid Onset of Inflammatory Bowel Disease after Receiving Secukinumab Infusion. ACG Case Rep J 5:e56
Horton, Brendan L; Gajewski, Thomas F (2018) Back from the dead: TIL apoptosis in cancer immune evasion. Br J Cancer 118:309-311
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Berni Canani, Roberto; De Filippis, Francesca; Nocerino, Rita et al. (2018) Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow's milk allergy. Sci Rep 8:12500
Kroeger, Marie E; Delmont, Tom O; Eren, A M et al. (2018) New Biological Insights Into How Deforestation in Amazonia Affects Soil Microbial Communities Using Metagenomics and Metagenome-Assembled Genomes. Front Microbiol 9:1635
Pierre, J F; Hinterleitner, R; Bouziat, R et al. (2018) Data on changes to mucosal inflammation and the intestinal microbiota following dietary micronutrients in genetically susceptible hosts. Data Brief 20:387-393
Krugliak Cleveland, Noa; Rubin, David T; Hart, John et al. (2018) Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis Frequently Have Subclinical Inflammation in the Proximal Colon. Clin Gastroenterol Hepatol 16:68-74

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