The overall goal of the Administrative Core of the University of Chicago (UChicago) Digestive Diseases Research Core Center (DDRCC) for Interdisciplinary Study of Inflammatory Intestinal Disorders (C-IID), is to provide leadership and strategic vision to foster and expand research in the field of inflammatory diseases of the bowel by its clinical and basic science faculty, particularly in the areas of microbiology, immunology, genetics/genomics and translational and clinical research. These themes have defined our GI program over 75 years ago when Dr. Joseph B Kirsner put forward the hypothesis that IBD was caused by genetic, immunological, and microbial factors. The C-IID Administrative Core leadership is provided by Dr. Bana Jabri, Director, Dr. Eugene Chang Co-Director, and Dr. John Alverdy, Associate Director with the help of their administrative staff and the C-IID Program Manager, in conjunction with the Executive Committee, the Internal Advisory Committee, and the External Advisory Committee. The Administrative Core will be responsible for overseeing all aspects of the C-IID, including strategic, scientific, and operational directions to insure effectiveness and impact of the program. It will continue to seek opportunities to foster interaction and collaborations among its members. It will also identify member needs, and optimize member benefits from Center Cores and Programs The administrative leadership also assures responsiveness of the C-IID Cores to the needs of the members and provides oversight for Core functions. This has led, for instance, to the addition of two computational scientists to help members with the analysis of host and microbial next-generation sequencing data, and the creation of the Multiparametric Host Cell Analysis core to promote utilization of state-of-the-art genomic technologies and enhance research in human immunology and tissue cell analysis in the field of DD. The proceedings of the monthly Executive Committee and Administrative Core meetings are reviewed on an annual basis by the Internal Advisory Board (comprised of selected, prominent, senior leaders in the Biological Sciences Division with expertise relevant to the goals of the C-IID) and the Dean of Biological Sciences, Dr. Kenneth Polonsky. The Executive Committee consists of C-IID leadership, prominent University of Chicago digestive diseases investigators. As the neutral review and sounding board, the External Advisory Board of the C- IID reviews all requests, reports, and recommendations of the Executive Committee. The members of the External Advisory Board include 5 internationally renowned investigators who are leaders in the area of digestive diseases, particularly in the focus areas of the C-IID. In summary, the Administrative Core of the C-IID provides leadership, programmatic vision, oversight, and management of a highly multidisciplinary and innovative program that foster interaction, collaboration, and synergy in studies of inflammatory diseases of the bowel.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK042086-31
Application #
10049111
Study Section
Special Emphasis Panel (ZDK1)
Project Start
1996-12-01
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
31
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Feagan, Brian G; Schwartz, David; Danese, Silvio et al. (2018) Efficacy of Vedolizumab in Fistulising Crohn's Disease: Exploratory Analyses of Data from GEMINI 2. J Crohns Colitis 12:621-626
Delmont, Tom O; Eren, A Murat (2018) Linking pangenomes and metagenomes: the Prochlorococcus metapangenome. PeerJ 6:e4320
Salas Garcia, Mariana C; Yee, Alyson L; Gilbert, Jack A et al. (2018) Dysbiosis in Children Born by Caesarean Section. Ann Nutr Metab 73 Suppl 3:24-32
Cardona, Cesar; Lax, Simon; Larsen, Peter et al. (2018) Environmental Sources of Bacteria Differentially Influence Host-Associated Microbial Dynamics. mSystems 3:
Micic, Dejan; Hirsch, Ayal; Setia, Namrata et al. (2018) Enteric infections complicating ulcerative colitis. Intest Res 16:489-493
He, Lei; Liu, Tianjing; Shi, Yongyan et al. (2018) Gut Epithelial Vitamin D Receptor Regulates Microbiota-Dependent Mucosal Inflammation by Suppressing Intestinal Epithelial Cell Apoptosis. Endocrinology 159:967-979
Wang, C-Z; Huang, W-H; Zhang, C-F et al. (2018) Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected]. Clin Transl Oncol 20:302-312
Kane, Melissa; Deiss, Felicity; Chervonsky, Alexander et al. (2018) A Single Locus Controls Interferon Gamma-Independent Antiretroviral Neutralizing Antibody Responses. J Virol 92:
Gaines, S; Shao, C; Hyman, N et al. (2018) Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery. Br J Surg 105:e131-e141
Wali, Ramesh K; Bianchi, Laura; Kupfer, Sonia et al. (2018) Prevention of colonic neoplasia with polyethylene glycol: A short term randomized placebo-controlled double-blinded trial. PLoS One 13:e0193544

Showing the most recent 10 out of 697 publications