The Pilot and Feasibility program at the University of Chicago (UChicago) Digestive Diseases Research Core Center (DDRCC) for Interdisciplinary Study of Inflammatory Intestinal Disorders (C-IID) is designed to provide a mechanism to promote new initiatives in digestive diseases (DD)-related research. The overall objectives of this program are to support investigations which would allow the development of preliminary data sufficient for grant funding by conventional mechanisms (pilot studies) or testing of an innovative hypothesis which might have important implications or yield significant results for digestive diseases related research (feasibility studies). Both of these broad aims have been pursued in the context of research focused on maintenance of homeostasis and an understanding of the pathobiology that accompanies intestinal inflammation. In the previous two renewal cycles (2010-2019), 45 P&F projects were awarded, and in the current period (2015-2019), 20 were awarded. The return on investment (ROI) over the past 10 years has exceeded 20:1. The P&F program remains an important vehicle for promoting multidisciplinary collaboration and a strong supportive scientific network for the young investigators funded by this program. Track I (new) investigators are given highest priority, followed by Tract II (non-DD) and Tract III (DD, new direction) investigators. We are requesting continuing support at the level of $110,000 per year. The funds will be combined with the $50,000 per year in supplemental funding committed by the GI section, bringing the total award amount to $160,000 or $30,000-37,500 for each award depending on the number of awards selected by the External Advisory Board. With the higher award size, the P&F awards are far more attractive to potential applicants and substantial enough to improve the odds that they will be successful in obtaining independent federal and extramural funding. A key feature of the program is the multi-disciplinary nature of the submitted proposals, coming from numerous departments, programs, and institutional affiliate within the University of Chicago network including the two of the University of Chicago affiliates, Argonne National Laboratory (ANL) and Marine Biological Laboratory (MBL). This large catchment of investigator talent reflects the overall scientific diversity of the research base of the C-IID. The P&F program has therefore made a difference for many investigators, fostered collaboration and interaction, pushed the envelope of scholarship and discovery, and is one of the jewels of our C-IID program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK042086-31
Application #
10049116
Study Section
Special Emphasis Panel (ZDK1)
Project Start
1996-12-01
Project End
2025-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
31
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Johnson, Carl D; Barlow-Anacker, Amanda J; Pierre, Joseph F et al. (2018) Deletion of choline acetyltransferase in enteric neurons results in postnatal intestinal dysmotility and dysbiosis. FASEB J 32:4744-4752
Pierre, Joseph F; Hinterleitner, Reinhard; Bouziat, Romain et al. (2018) Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility. J Nutr Biochem 54:95-104
Williams Jr, James C; Borofsky, Michael S; Bledsoe, Sharon B et al. (2018) Papillary Ductal Plugging is a Mechanism for Early Stone Retention in Brushite Stone Disease. J Urol 199:186-192
Micic, Dejan; Yarur, Andres; Gonsalves, Alex et al. (2018) Risk Factors for Clostridium difficile Isolation in Inflammatory Bowel Disease: A Prospective Study. Dig Dis Sci 63:1016-1024
Brown, Hailey M; Biering, Scott B; Zhu, Allen et al. (2018) Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon-Inducible GTPases. Bioessays 40:e1700231
Lu, Lei; Claud, Erika C (2018) Intrauterine Inflammation, Epigenetics, and Microbiome Influences on Preterm Infant Health. Curr Pathobiol Rep 6:15-21
Lu, Jing; Synowiec, Sylvia; Lu, Lei et al. (2018) Microbiota influence the development of the brain and behaviors in C57BL/6J mice. PLoS One 13:e0201829
Shiloh, Ruth; Gilad, Yuval; Ber, Yaara et al. (2018) Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy. Nat Commun 9:1759
Wang, Haitao; Cheng, Minying; Dsouza, Melissa et al. (2018) Soil Bacterial Diversity Is Associated with Human Population Density in Urban Greenspaces. Environ Sci Technol 52:5115-5124
Khambu, Bilon; Huda, Nazmul; Chen, Xiaoyun et al. (2018) HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers. J Clin Invest 128:2419-2435

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