Abstract

application) This core is designed to provide cost effective immunology research services to center investigators, serves as a repository for reagents such as hybridomas, and provides education in the use of educational techniques. The range of techniques provided includes preparation of monoclonal antibodies, protein analysis, flow cytometry (FACSCAN), purification of IELs and LPLs, T and B lymphocyte function assays, ELISA and RIAs, and assays of cytokines. The core has two locations. The primary location is at MGH east, where two benches and shared resources are dedicated to the center, and a second location at MGH is dedicated to monoclonal preparation. The core director is Dr. Allan Walker, with co directors Dr. Nagler-Anderson at MGH east and Dr. Takahashi at MGH. There is a 100% technician at MGH east whose primary work is to support flow cytometry and T and B cell assays, and a 50% technician at MGH to produce monoclonal antibodies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK043351-12
Application #
6564268
Study Section
Project Start
2002-01-01
Project End
2002-12-31
Budget Start
Budget End
Support Year
12
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Wein, Marc N; Foretz, Marc; Fisher, David E et al. (2018) Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential. Trends Endocrinol Metab 29:723-735
Graham, Daniel B; Jasso, Guadalupe J; Mok, Amanda et al. (2018) Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes. Cell Rep 24:838-850
Vedamurthy, Amar; Xu, Louise; Luther, Jay et al. (2018) Long-Term Outcomes of Immunosuppression-Naïve Steroid Responders Following Hospitalization for Ulcerative Colitis. Dig Dis Sci 63:2740-2746
Simon, Tracey G; Van Der Sloot, Kimberley W J; Chin, Samantha B et al. (2018) IRGM Gene Variants Modify the Relationship Between Visceral Adipose Tissue and NAFLD in Patients With Crohn's Disease. Inflamm Bowel Dis 24:2247-2257
Schirmer, Melanie; Denson, Lee; Vlamakis, Hera et al. (2018) Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course. Cell Host Microbe 24:600-610.e4
Zhang, Wei; Jiao, Lefei; Liu, Ruixin et al. (2018) The effect of exposure to high altitude and low oxygen on intestinal microbial communities in mice. PLoS One 13:e0203701
Yassour, Moran; Jason, Eeva; Hogstrom, Larson J et al. (2018) Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life. Cell Host Microbe 24:146-154.e4
Akcakaya, Pinar; Bobbin, Maggie L; Guo, Jimmy A et al. (2018) In vivo CRISPR editing with no detectable genome-wide off-target mutations. Nature 561:416-419
Kim, Byeong-Moo; Abdelfattah, Ahmed Maher; Vasan, Robin et al. (2018) Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis. Sci Rep 8:7499
Burke, Kristin E; Ananthakrishnan, Ashwin N; Lochhead, Paul et al. (2018) Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women. J Crohns Colitis 12:559-567

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