Abstract

application) This core is designed to provide cost effective immunology research services to center investigators, serves as a repository for reagents such as hybridomas, and provides education in the use of educational techniques. The range of techniques provided includes preparation of monoclonal antibodies, protein analysis, flow cytometry (FACSCAN), purification of IELs and LPLs, T and B lymphocyte function assays, ELISA and RIAs, and assays of cytokines. The core has two locations. The primary location is at MGH east, where two benches and shared resources are dedicated to the center, and a second location at MGH is dedicated to monoclonal preparation. The core director is Dr. Allan Walker, with co directors Dr. Nagler-Anderson at MGH east and Dr. Takahashi at MGH. There is a 100% technician at MGH east whose primary work is to support flow cytometry and T and B cell assays, and a 50% technician at MGH to produce monoclonal antibodies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK043351-12
Application #
6564268
Study Section
Project Start
2002-01-01
Project End
2002-12-31
Budget Start
Budget End
Support Year
12
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Kanneganti, Apurva; Malireddi, R K Subbarao; Saavedra, Pedro H V et al. (2018) GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever. J Exp Med 215:1519-1529
Duan, Xiaoqiong; Li, Shilin; Holmes, Jacinta A et al. (2018) MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway. J Virol 92:
Mehta, Raaj S; Abu-Ali, Galeb S; Drew, David A et al. (2018) Stability of the human faecal microbiome in a cohort of adult men. Nat Microbiol 3:347-355
Nguyen, Long H; Lochhead, Paul; Joshi, Amit D et al. (2018) No Significant Association Between Proton Pump Inhibitor Use and Risk of Stroke After Adjustment for Lifestyle Factors and Indication. Gastroenterology 154:1290-1297.e1
Kochar, Bharati; Barnes, Edward L; Herfarth, Hans H et al. (2018) Asians have more perianal Crohn disease and ocular manifestations compared with white Americans. Inflamm Intest Dis 2:147-153
Burke, Kristin E; Ananthakrishnan, Ashwin N; Lochhead, Paul et al. (2018) Identification of Menopausal and Reproductive Risk Factors for Microscopic Colitis-Results From the Nurses' Health Study. Gastroenterology 155:1764-1775.e2
Cuenca, Marta; Puñet-Ortiz, Joan; Ruart, Maria et al. (2018) Ly9 (SLAMF3) receptor differentially regulates iNKT cell development and activation in mice. Eur J Immunol 48:99-105
Liu, Li; Tabung, Fred K; Zhang, Xuehong et al. (2018) Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol 16:1622-1631.e3
Staller, K; Barshop, K; Ananthakrishnan, A N et al. (2018) Number of retained radiopaque markers on a colonic transit study does not correlate with symptom severity or quality of life in chronic constipation. Neurogastroenterol Motil 30:e13269
Shi, Hai Yun; Levy, Alexander N; Trivedi, Hirsh D et al. (2018) Ethnicity Influences Phenotype and Outcomes in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis of Population-based Studies. Clin Gastroenterol Hepatol 16:190-197.e11

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