The Human Genetics and Microbiome Core will be co-directed by Mark Daly and Curtis Huttenhower. The services offered within this core are composed of a suite of services from more routine and heavily used molecular biology services (e.g., whole plasmid DNA sequencing) to computationally complex tools to analyze the role of genetics and the microbiome in IBD (e.g., statistical association testing between host genotypes and microbiome).Central to all services are formal and informal end-to-end consultations and training on experimental design, data generation, and bioinformatics analysis. A team of bioinformaticists and software developers with in-depth expertise are available within the Core to provide collaborative capacity for analysis of genetics, microbiome, and/or functional data This core will be a major connection point for clinicians and basic researchers, as it operates at the intersection between patient samples and basic research techniques.
The specific aims of Human Genetics and Microbiome Core are divided according to its two themes. For genetics, the Core will (1) facilitate the application of advanced experimental platforms for genetics, genomics, and high-throughput data analysis to discovery efforts relevant to IBD; (2) provide a centralized facility and personnel for performing state-of-the-art recombinant and PCR-based DNA procedures and RNA interference and provide cost-effective and high- quality molecular biology reagents and services; and (3) provide a resource for disseminating a wide range of molecular biology, genetic, and bioinformatics technologies. For microbiome services, the Core will (1) provide an end-to-end sampling and multi?omic profiling system for the host and microbiota in IBD and gastrointestinal disease; (2) provide computational resources to analyze and interpret the microbiome; and (3) develop cutting-edge solutions in microbiome research that will drive therapeutic discovery.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK043351-27
Application #
9253375
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2017-01-01
Budget End
2017-12-31
Support Year
27
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114
Staller, K; Barshop, K; Ananthakrishnan, A N et al. (2018) Number of retained radiopaque markers on a colonic transit study does not correlate with symptom severity or quality of life in chronic constipation. Neurogastroenterol Motil 30:e13269
Cuenca, Marta; Puñet-Ortiz, Joan; Ruart, Maria et al. (2018) Ly9 (SLAMF3) receptor differentially regulates iNKT cell development and activation in mice. Eur J Immunol 48:99-105
Liu, Li; Tabung, Fred K; Zhang, Xuehong et al. (2018) Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol 16:1622-1631.e3
Shi, Hai Yun; Levy, Alexander N; Trivedi, Hirsh D et al. (2018) Ethnicity Influences Phenotype and Outcomes in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis of Population-based Studies. Clin Gastroenterol Hepatol 16:190-197.e11
Vujic, Ana; Lerchenmüller, Carolin; Wu, Ting-Di et al. (2018) Exercise induces new cardiomyocyte generation in the adult mammalian heart. Nat Commun 9:1659
He, Xiaosheng; Wu, Kana; Ogino, Shuji et al. (2018) Association Between Risk Factors for Colorectal Cancer and Risk of Serrated Polyps and Conventional Adenomas. Gastroenterology 155:355-373.e18
Haberman, Yael; Schirmer, Melanie; Dexheimer, Phillip J et al. (2018) Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis. Mucosal Immunol :
Mohanan, Vishnu; Nakata, Toru; Desch, A Nicole et al. (2018) C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Science 359:1161-1166
Aktar, Amena; Rahman, M Arifur; Afrin, Sadia et al. (2018) Plasma and memory B cell responses targeting O-specific polysaccharide (OSP) are associated with protection against Vibrio cholerae O1 infection among household contacts of cholera patients in Bangladesh. PLoS Negl Trop Dis 12:e0006399
Gibbons, Sean M; Duvallet, Claire; Alm, Eric J (2018) Correcting for batch effects in case-control microbiome studies. PLoS Comput Biol 14:e1006102

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