The Clinical Core will be led by Ramnik Xavier (Director), Andrew Chan (Co-Director), and Ashwin Ananthakrishnan (Technical Director). The services offered by the Clinical Core can be organized into (1) consultation, training, and education; (2) biospecimen services; and (3) data collection and analysis services. Consultation and education take the form of consulting in research methods and analysis, as well as education and training of junior investigators, residents, and fellows. Biospecimen services include clinical database and patient identification, biospecimen collection and processing services, tissue biorepository services, and serum biobank services. Data collection and analysis is facilitated through regulatory services, a genotype and microbiome library, and bioinformatics support. This core serves as a hub for interactions between clinicians and basic researchers, allowing basic scientists to test hypotheses in human samples and clinicians to gain valuable insight into disease states.
The specific aims of the Clinical Core are to (1) build a biorepository of patients with Crohn?s disease and ulcerative colitis with accurate phenotyping of disease as well as sampling of blood, stool, urine, and tissue in various disease states (active/inactive disease) and related to various therapeutic and environmental perturbations; (2) define the phenotypic implications of genetic loci with regard to clinical manifestations, response to therapy, and to examine the interaction with the environment; (3) facilitate education and training in research by providing consultations regarding study design, methods, and analysis as well as attract new investigators to the field through these services; and (4) translate laboratory and clinical research findings into interventions that serve to improve diagnosis, develop biomarkers for disease monitoring and prognostication, and optimize treatment algorithms.
|Haberman, Yael; Schirmer, Melanie; Dexheimer, Phillip J et al. (2018) Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis. Mucosal Immunol :|
|Mohanan, Vishnu; Nakata, Toru; Desch, A Nicole et al. (2018) C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Science 359:1161-1166|
|Aktar, Amena; Rahman, M Arifur; Afrin, Sadia et al. (2018) Plasma and memory B cell responses targeting O-specific polysaccharide (OSP) are associated with protection against Vibrio cholerae O1 infection among household contacts of cholera patients in Bangladesh. PLoS Negl Trop Dis 12:e0006399|
|Gibbons, Sean M; Duvallet, Claire; Alm, Eric J (2018) Correcting for batch effects in case-control microbiome studies. PLoS Comput Biol 14:e1006102|
|Barshop, Kenneth; Willingham, Field F; Brugge, William R et al. (2018) EMR is superior to rectal suction biopsy for analysis of enteric ganglia in constipation and dysmotility. Gastrointest Endosc 87:876-880|
|Sorensen, Elizabeth W; Lian, Jeffrey; Ozga, Aleksandra J et al. (2018) CXCL10 stabilizes T cell-brain endothelial cell adhesion leading to the induction of cerebral malaria. JCI Insight 3:|
|Zhang, Sidi; Samocha, Kaitlin E; Rivas, Manuel A et al. (2018) Base-specific mutational intolerance near splice sites clarifies the role of nonessential splice nucleotides. Genome Res 28:968-974|
|Beaulieu, Dawn B; Ananthakrishnan, Ashwin N; Martin, Christopher et al. (2018) Use of Biologic Therapy by Pregnant Women With Inflammatory Bowel Disease Does Not Affect Infant Response to Vaccines. Clin Gastroenterol Hepatol 16:99-105|
|Hui, Ken Y; Fernandez-Hernandez, Heriberto; Hu, Jianzhong et al. (2018) Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease. Sci Transl Med 10:|
|Chong, Dawn Q; Banbury, Barbara L; Phipps, Amanda I et al. (2018) Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies. Cancer Med 7:2192-2199|
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