Abstract

This application represents the competing renewal of the Boston Obesity/Nutrition Research Center. The Boston Obesity/Nutrition Research Center represents a collaboration of four major institutions representing three major universities in Boston, all located within a 1.5 mile radius of each other. The Boston Obesity Center includes the New England Medical Center, the Beth Israel Deaconess Medical Center, the Harvard School of Public Health, and Boston Medical Center. The institutions represent respectively Tufts University, Harvard University, and Boston University. The Boston Obesity/Nutrition Research Center consists of five Core Laboratories. These includes an Epidemiology Core, directed by Dr. Graham Colditz at the Harvard School of Public Health, a Clinical/Metabolic Core, directed by Dr. George Blackburn at the Beth Israel Deaconess Medical Center, a Body Composition/Energy Expenditure Core, directed b Dr. William Dietz at the New England Medical Center, an Adipocyte Core, initially designed as a Cellular Biochemistry Signal Transduction Core, at Boston Medical Center, now directed by Dr. James Kirkland, and a Transgenic Core at the Beth Israel Deaconess Medical Center directed by Dr. Jeffrey Flier. The Obesity Center offers multiple opportunities for education and training in obesity research to fellows on training grants held by Obesity Center investigators in each of the collaborating universities. The investigators represented in this application hold 65 funded R0-1 grants, approximately 45 which are directed at the study of obesity, energy metabolism or other nutritional disease. In the past four years, Boston Obesity Center investigators have published 135 papers with Center support. Twenty percent of the Obesity Center budget provide support for pilot and feasibility studies. Pilot and feasibility award recipients have published almost 50 papers and received a total of 7 grants from NIH or other funding agencies based on the data obtained from their Center funded investigations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
7P30DK046200-07
Application #
2796580
Study Section
Special Emphasis Panel (ZDK1-GRB-7 (M1))
Program Officer
Hubbard, Van S
Project Start
1992-09-30
Project End
2002-09-29
Budget Start
1998-09-30
Budget End
1999-09-29
Support Year
7
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Keum, NaNa; Ha, Kyoung Hwa; Bao, Ying et al. (2018) Long-term patterns of fasting blood glucose levels and pancreatic cancer incidence. Cancer Causes Control 29:135-142
Dong, Kimberly R; Tang, Alice M; Stopka, Thomas J et al. (2018) Food acquisition methods and correlates of food insecurity in adults on probation in Rhode Island. PLoS One 13:e0198598
Sun, D; Wang, T; Heianza, Y et al. (2018) Birthweight and cardiometabolic risk patterns in multiracial children. Int J Obes (Lond) 42:20-27
Heianza, Yoriko; Sun, Dianjianyi; Ma, Wenjie et al. (2018) Gut-microbiome-related LCT genotype and 2-year changes in body composition and fat distribution: the POUNDS Lost Trial. Int J Obes (Lond) 42:1565-1573
Leitner, Brooks P; Weiner, Lauren S; Desir, Matthew et al. (2018) Kinetics of human brown adipose tissue activation and deactivation. Int J Obes (Lond) :
Killion, Elizabeth A; Reeves, Andrew R; El Azzouny, Mahmoud A et al. (2018) A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction. Mol Metab 9:43-56
Hansen, S; Halldorsson, T I; Olsen, S F et al. (2018) Birth by cesarean section in relation to adult offspring overweight and biomarkers of cardiometabolic risk. Int J Obes (Lond) 42:15-19
Gaskins, Audrey J; Rich-Edwards, Janet W; Williams, Paige L et al. (2018) Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion. Eur J Nutr 57:107-117
Han, Liyuan; Duan, Donghui; Zhang, Shuang et al. (2018) Effects of the interaction between glycated haemoglobin genetic risk score and postpartum weight reduction on glycaemic changes: A gene-weight interaction analysis. Diabetes Obes Metab 20:2733-2739
Maldonado-Cárceles, Ana B; Mínguez-Alarcón, Lidia; Mendiola, Jaime et al. (2018) Meat intake in relation to semen quality and reproductive hormone levels among young men in Spain. Br J Nutr :1-10

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