Abstract

The objectives of this core are to provide: 1. A service facility that wil utilize investigator-derived DNA constructs to create founder transgenic and gene knockout mice that can be used to address questions relevant to obesity and nutrition research; 2. Consultations to obesity and nutrition researchers regarding general aspects of transgenic and gene knockout work, the use of tissue-specific promoters, the generation of transgenic and gene knockout constructs, and the establishment and monitoring of genetically modified mouse colonies; and 3. Training in methods required for the generation of transgenic and gene knockout DNA constructs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
7P30DK046200-07
Application #
6105543
Study Section
Project Start
1998-09-30
Project End
1999-09-29
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
7
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Todd, William D; Fenselau, Henning; Wang, Joshua L et al. (2018) A hypothalamic circuit for the circadian control of aggression. Nat Neurosci 21:717-724
Perng, Wei; Rifas-Shiman, Sheryl L; Hivert, Marie-France et al. (2018) Branched Chain Amino Acids, Androgen Hormones, and Metabolic Risk Across Early Adolescence: A Prospective Study in Project Viva. Obesity (Silver Spring) 26:916-926
Kim, Hanseul; Keum, NaNa; Giovannucci, Edward L et al. (2018) Garlic intake and gastric cancer risk: Results from two large prospective US cohort studies. Int J Cancer 143:1047-1053
Heianza, Yoriko; Sun, Dianjianyi; Smith, Steven R et al. (2018) Changes in Gut Microbiota-Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial. Diabetes Care 41:413-419
Chistol, Liem T; Bandini, Linda G; Must, Aviva et al. (2018) Sensory Sensitivity and Food Selectivity in Children with Autism Spectrum Disorder. J Autism Dev Disord 48:583-591
Thomas, Dylan D; Istfan, Nawfal W; Bistrian, Bruce R et al. (2018) Protein sparing therapies in acute illness and obesity: a review of George Blackburn's contributions to nutrition science. Metabolism 79:83-96
Sarma, Elizabeth A; Kawachi, Ichiro; Poole, Elizabeth M et al. (2018) Social integration and survival after diagnosis of colorectal cancer. Cancer 124:833-840
Li, Jun; Rice, Megan S; Huang, Tianyi et al. (2018) Circulating prolactin concentrations and risk of type 2 diabetes in US women. Diabetologia 61:2549-2560
Chiu, Yu-Han; Williams, Paige L; Gillman, Matthew W et al. (2018) Maternal intake of pesticide residues from fruits and vegetables in relation to fetal growth. Environ Int 119:421-428
Heianza, Yoriko; Sun, Dianjianyi; Li, Xiang et al. (2018) Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial. Gut :

Showing the most recent 10 out of 876 publications