This application represents the third competing renewal of the Boston Obesity Nutrition Research Center. The Boston Obesity Nutrition Research Center represents a collaboration of three major universities representing six major organizations, all located within a 1.5 mile radius of one another. The Boston Obesity Center includes Tufts-New England Medical Center, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Harvard School of Public Health, Boston Medical Center and the Human Nutrition Research Center on Aging. These institutions represent Tufts University, Harvard University and Boston University, respectively The research base has increased from 97 to 163 and includes members from these institutions as well as several new ones, including the University of Massachusetts Boston and the University of Massachusetts Medical School (Worcester) and it affiliated University Center for Excellence in Developmental Disabilities at the Eunice Kennedy Shriver Center in Waltham. The Boston Obesity Nutrition Research Center consists of four Core laboratories. These include an Adipocyte Core directed by Dr. James Kirkland, a Clinical and Community Research Core directed by Dr. Aviva Must, an Epidemiology and Genetics Core directed by Dr. Frank Hu and a Transgenic Core directed by Dr. Bradford Lowell. The Obesity Center offers many opportunities for education and training in obesity research to fellows on training grants held by Obesity Center investigators in each of the collaborating institutions. The investigators represented in this application are Principal Investigators on 171 funded NIH grants, approximately 143 of which are directed at the study of obesity, energy metabolism or other nutritional diseases. In the past five years, the Boston Obesity Center investigators have published 283 papers with Center support. Currently, fifteen percent of the Obesity Center's budget provides support for pilot and feasibility studies. Pilot and feasibility award recipients have published 640 papers and received a total of 41 grants from NIH or other funding agencies based on the data obtained from their Center-funded and subsequent research in obesity and nutrition.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK046200-17
Application #
7626351
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (J1))
Program Officer
Miles, Carolyn
Project Start
1997-09-30
Project End
2013-03-31
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
17
Fiscal Year
2009
Total Cost
$1,087,234
Indirect Cost
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118
Marron, Elena M; Viejo-Sobera, Raquel; Cuatrecasas, Guillem et al. (2018) Prefronto-cerebellar neuromodulation affects appetite in obesity. Int J Obes (Lond) :
Dong, Kimberly R; Must, Aviva; Tang, Alice M et al. (2018) Food Insecurity, Morbidities, and Substance Use in Adults on Probation in Rhode Island. J Urban Health 95:564-575
Chiu, Yu-Han; Bertrand, Kimberly A; Zhang, Shumin et al. (2018) A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma. Int J Cancer 143:1914-1922
Yamamoto, Ayae; Harris, Holly R; Vitonis, Allison F et al. (2018) A prospective cohort study of meat and fish consumption and endometriosis risk. Am J Obstet Gynecol 219:178.e1-178.e10
Todd, William D; Fenselau, Henning; Wang, Joshua L et al. (2018) A hypothalamic circuit for the circadian control of aggression. Nat Neurosci 21:717-724
Perng, Wei; Rifas-Shiman, Sheryl L; Hivert, Marie-France et al. (2018) Branched Chain Amino Acids, Androgen Hormones, and Metabolic Risk Across Early Adolescence: A Prospective Study in Project Viva. Obesity (Silver Spring) 26:916-926
Kim, Hanseul; Keum, NaNa; Giovannucci, Edward L et al. (2018) Garlic intake and gastric cancer risk: Results from two large prospective US cohort studies. Int J Cancer 143:1047-1053
Heianza, Yoriko; Sun, Dianjianyi; Smith, Steven R et al. (2018) Changes in Gut Microbiota-Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial. Diabetes Care 41:413-419
Chistol, Liem T; Bandini, Linda G; Must, Aviva et al. (2018) Sensory Sensitivity and Food Selectivity in Children with Autism Spectrum Disorder. J Autism Dev Disord 48:583-591
Thomas, Dylan D; Istfan, Nawfal W; Bistrian, Bruce R et al. (2018) Protein sparing therapies in acute illness and obesity: a review of George Blackburn's contributions to nutrition science. Metabolism 79:83-96

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