Abstract

A. Purpose ? To provide a service facilitv that will utilize investigator-derived DNA constructs or investigator derived (or obtained) genetically modified embryonic stem cells to create founder transgenic and gene knockout or knockin mice (i.e mice bearing point mutants, lox-modified or ires/2A-Cre knockin alleles) that can be used to address questions relevant to obesity, diabetes and nutrition, including questions related to brain control of feeding, metabolism and reward. ? To provide consultation and training on all aspects of making and using genetically modified mice.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK046200-21
Application #
8509881
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (J3))
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
21
Fiscal Year
2013
Total Cost
$254,654
Indirect Cost

  Institution

Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Fadelu, Temidayo; Zhang, Sui; Niedzwiecki, Donna et al. (2018) Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance). J Clin Oncol 36:1112-1120
Ross, Rachel A; Leon, Silvia; Madara, Joseph C et al. (2018) PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse. Elife 7:
Ramesh, Rohan N; Burgess, Christian R; Sugden, Arthur U et al. (2018) Intermingled Ensembles in Visual Association Cortex Encode Stimulus Identity or Predicted Outcome. Neuron 100:900-915.e9
Chiu, Yu-Han; Williams, Paige L; Mínguez-Alarcón, Lidia et al. (2018) Comparison of questionnaire-based estimation of pesticide residue intake from fruits and vegetables with urinary concentrations of pesticide biomarkers. J Expo Sci Environ Epidemiol 28:31-39
Dong, Kimberly R; Tang, Alice M; Stopka, Thomas J et al. (2018) Food acquisition methods and correlates of food insecurity in adults on probation in Rhode Island. PLoS One 13:e0198598
Keum, NaNa; Ha, Kyoung Hwa; Bao, Ying et al. (2018) Long-term patterns of fasting blood glucose levels and pancreatic cancer incidence. Cancer Causes Control 29:135-142
Heianza, Yoriko; Sun, Dianjianyi; Ma, Wenjie et al. (2018) Gut-microbiome-related LCT genotype and 2-year changes in body composition and fat distribution: the POUNDS Lost Trial. Int J Obes (Lond) 42:1565-1573
Sun, D; Wang, T; Heianza, Y et al. (2018) Birthweight and cardiometabolic risk patterns in multiracial children. Int J Obes (Lond) 42:20-27
Killion, Elizabeth A; Reeves, Andrew R; El Azzouny, Mahmoud A et al. (2018) A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction. Mol Metab 9:43-56
Leitner, Brooks P; Weiner, Lauren S; Desir, Matthew et al. (2018) Kinetics of human brown adipose tissue activation and deactivation. Int J Obes (Lond) :

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