Abstract

The Boston Nutrition Obesity Research Center (BNORC) was founded in 1992 and has been administratively based at Boston Medical Center (BMC) for the past 15 years. The BNORC consortium is a collaboration of Boston, Tufts, and Harvard Universities and serves nutrition and obesity scientists in the Boston area. The overall objective of BNORC is to 1) facilitate and support the conduct of cutting edge basic and translational research in the fields of nutrition and obesity science, and 2) provide resources and educational opportunities that enrich the training of new investigators and promote multi- and interdisciplinary research collaborations. Four Cores serve these goals: A) Administrative (S.K. Fried, Director), B) Adipose Biology and Nutnent Metabolism (S.K. Fried and A.S. Greenberg), C) Clinical and Community Research (A. Must and E. Goodman), D) Epidemiology and Genetics (F. Hu and J. Chavarro), and E) Transgenic (B. Lowell). The BNORC research base includes 164 members with $42 million of nutrition and obesity related federal funding (24.0% NIDDK; 70% federal). These scientists address basic, clinical and population aspects of four interrelated themes: 1) Nutrient Metabolism in Health and Disease; 2) Brain Control of Feeding Behavior and Metabolism; 3) Environmental and Genetic Influence of Obesity and Related Chronic Diseases; and 4) Multi-level, Lifecourse Approaches to Nutrition and Obesity -related Diseases. Substantial resources are dedicated to our Pilot and Feasibility Program which has supported the early careers of many prominent scientists in the field.

Public Health Relevance

Approximately 34% of adult Americans and 18% of children are obese, substantially increasing the risk of a number of chronic diseases such as diabetes, heart disease, osteoarthritis and some cancers. Diet quality also affects risk of chronic disease. By bridging disciplines and promoting collaborations, the Boston Nutrition Obesity Research Center fosters the development of strategies to improve the health of many of our citizens.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
4P30DK046200-24
Application #
9263378
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Evans, Mary
Project Start
Project End
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
24
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Bray, George A; Heisel, William E; Afshin, Ashkan et al. (2018) The Science of Obesity Management: An Endocrine Society Scientific Statement. Endocr Rev 39:79-132
Hou, Xiaoli; Zhang, Yongzhao; Li, Wei et al. (2018) CDK6 inhibits white to beige fat transition by suppressing RUNX1. Nat Commun 9:1023
Nassan, Feiby L; Chiu, Yu-Han; Vanegas, Jose C et al. (2018) Intake of protein-rich foods in relation to outcomes of infertility treatment with assisted reproductive technologies. Am J Clin Nutr 108:1104-1112
Mínguez-Alarcón, Lidia; Afeiche, Myriam C; Williams, Paige L et al. (2018) Hair mercury (Hg) levels, fish consumption and semen parameters among men attending a fertility center. Int J Hyg Environ Health 221:174-182
Harris, H R; Eke, A C; Chavarro, J E et al. (2018) Fruit and vegetable consumption and risk of endometriosis. Hum Reprod 33:715-727
Arvizu, Mariel; Afeiche, Myriam C; Hansen, Susanne et al. (2018) Fat intake during pregnancy and risk of preeclampsia: a prospective cohort study in Denmark. Eur J Clin Nutr :
Nisa, Hoirun; Qi, Kevin H T; Leng, Junhong et al. (2018) The Circadian Rhythm-Related MTNR1B Genotype, Gestational Weight Gain, and Postpartum Glycemic Changes. J Clin Endocrinol Metab 103:2284-2290
Kong, Xingxing; Yao, Ting; Zhou, Peng et al. (2018) Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metab 28:631-643.e3
Sun, Dianjianyi; Li, Xiang; Heianza, Yoriko et al. (2018) History of Asthma From Childhood and Arterial Stiffness in Asymptomatic Young Adults: The Bogalusa Heart Study. Hypertension 71:928-936
Chiu, Yu-Han; Williams, Paige L; Gillman, Matthew W et al. (2018) Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology. JAMA Intern Med 178:17-26

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