The Epidemiology and Genetics (E&G) Core, under the direction of Dr. Frank Hu, provides members with access to data and biological specimen banks from large prospective cohort studies including the Nurses' Health Studies (based at Brigham Women's Hospital), the Health Professionals Health Study (based at the Harvard School of Public Health), the Framingham Heart Study (based at Boston University), Project Viva (based at Harvard Medical School), Boston Puerto Rican Health Study (based at Northeastern University and Tufts University). The Core also provides consultation services in design and analysis for epidemiologic studies with a focus on obesity and nutrition (as exposure or outcome) and for epidemiologic studies aimed at understanding the biologic basis of obesity and related phenotypes through the use of genetics and ?omics technologies. The resources offered by the core have been central to the contributions of large GWAS studies including the GIANT consortium (based at Broad Institute and Children's Hospital) and CHARGE consortium (based at MGH), and fosters bidirectional cross-talk between basic and population scientists in the analysis of candidate genes for obesity and altered nutrient metabolism and on the translation of findings in animal models to human populations. In the last 4-year cycle (2012-2016) services provided by the core resulted in the publication of 170 manuscripts ?an increase from 124 in the previous 5-year competitive renewal cycle (2007- 2012)? including 13 manuscripts published in high impact medical journals (NEJM, JAMA, Lancet, BMJ). In this competitive renewal we propose to further expand data access to include cohorts where hypotheses regarding intergenerational effects of parental exposures on offspring obesity and related phenotypes can be tested, as well as expanded access to and analytical support for projects involving metabolomics and gut microbiome data from the prospective cohorts available through the core.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK046200-27
Application #
9699471
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2019-06-01
Budget End
2020-05-31
Support Year
27
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118
Leitner, Brooks P; Weiner, Lauren S; Desir, Matthew et al. (2018) Kinetics of human brown adipose tissue activation and deactivation. Int J Obes (Lond) :
Killion, Elizabeth A; Reeves, Andrew R; El Azzouny, Mahmoud A et al. (2018) A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction. Mol Metab 9:43-56
Hansen, S; Halldorsson, T I; Olsen, S F et al. (2018) Birth by cesarean section in relation to adult offspring overweight and biomarkers of cardiometabolic risk. Int J Obes (Lond) 42:15-19
Gaskins, Audrey J; Rich-Edwards, Janet W; Williams, Paige L et al. (2018) Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion. Eur J Nutr 57:107-117
Han, Liyuan; Duan, Donghui; Zhang, Shuang et al. (2018) Effects of the interaction between glycated haemoglobin genetic risk score and postpartum weight reduction on glycaemic changes: A gene-weight interaction analysis. Diabetes Obes Metab 20:2733-2739
Maldonado-Cárceles, Ana B; Mínguez-Alarcón, Lidia; Mendiola, Jaime et al. (2018) Meat intake in relation to semen quality and reproductive hormone levels among young men in Spain. Br J Nutr :1-10
Cardamone, Maria Dafne; Tanasa, Bogdan; Cederquist, Carly T et al. (2018) Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Mol Cell 69:757-772.e7
Jager, Mike; Lee, Mi-Jeong; Li, Chendi et al. (2018) Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue. PLoS One 13:e0197777
Buendia, Justin R; Li, Yanping; Hu, Frank B et al. (2018) Regular Yogurt Intake and Risk of Cardiovascular Disease Among Hypertensive Adults. Am J Hypertens 31:557-565
Martin Carli, Jayne F; LeDuc, Charles A; Zhang, Yiying et al. (2018) FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications. J Lipid Res 59:1446-1460

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