Obesity is a major public health problem in this country. Currently the mechanisms which underlie the development of obesity are obscure. While a complex interaction between nutrient intake, energy expenditure and fuel metabolism exists, evidence in humans and laboratory animals suggests that abnormal partitioning of triglyceride fatty acids (TGFA) favoring storage over oxidation may play a central role in the development of some forms of obesity. it is hypothesized that defects in the oxidation and storage of lipid fuel within skeletal muscle play an important role in the development and maintenance of the obese state by shunting dietary fat towards storage in adipose tissue. The goal of the research projects proposed is to test this hypothesis by following the metabolic fate of lipid fuels in skeletal muscle from lean and obese rats. In addition the enzyme systems responsible for the metabolism of fatty acids within skeletal muscle will be examined in detail. Over the last 20 years radioactive tracer studies have shed important new light on the abnormalities of carbohydrate metabolism which are present in obesity and type II diabetes. Studies of TGFA metabolism however have lagged far behind, and yet may provide important insights into the mechanisms which underlie the development and maintenance of obesity.

Project Start
1997-01-01
Project End
1997-12-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Erlandson, Kristine M; Lake, Jordan E; Sim, Myung et al. (2018) Bone Mineral Density Declines Twice as Quickly Among HIV-Infected Women Compared With Men. J Acquir Immune Defic Syndr 77:288-294
Kuwabara, Masanari; Hisatome, Ichiro; Niwa, Koichiro et al. (2018) Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study. Hypertension 71:78-86
Peppler, Willem T; Townsend, Logan K; Knuth, Carly M et al. (2018) Subcutaneous inguinal white adipose tissue is responsive to, but dispensable for, the metabolic health benefits of exercise. Am J Physiol Endocrinol Metab 314:E66-E77
Bellows, Laura L; McCloskey, Morgan; Clark, Lauren et al. (2018) HEROs: Design of a Mixed-Methods Formative Research Phase for an Ecocultural Intervention to Promote Healthy Eating and Activity Behaviors in Rural Families With Preschoolers. J Nutr Educ Behav :
Lake, Jordan E; Li, Xiuhong; Palella Jr, Frank J et al. (2018) Metabolic health across the BMI spectrum in HIV-infected and HIV-uninfected men. AIDS 32:49-57
Jovanovich, Anna; Isakova, Tamara; Block, Geoffrey et al. (2018) Deoxycholic Acid, a Metabolite of Circulating Bile Acids, and Coronary Artery Vascular Calcification in CKD. Am J Kidney Dis 71:27-34
Hill, James M; O'Leary, Joseph (2018) Generalized transformations and coordinates for static spherically symmetric general relativity. R Soc Open Sci 5:171109
Diab, Liliane; Krebs, Nancy F (2018) Vitamin Excess and Deficiency. Pediatr Rev 39:161-179
Bjornstad, Petter; Cree-Green, Melanie; Baumgartner, Amy et al. (2018) Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtform Pediatr Diabetes 19:436-442
Cintron, Dahima; Lahr, Brian D; Bailey, Kent R et al. (2018) Effects of oral versus transdermal menopausal hormone treatments on self-reported sleep domains and their association with vasomotor symptoms in recently menopausal women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS). Menopause 25:145-153

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