Abstract

Obesity is a major public health problem in this country. Currently the mechanisms which underlie the development of obesity are obscure. While a complex interaction between nutrient intake, energy expenditure and fuel metabolism exists, evidence in humans and laboratory animals suggests that abnormal partitioning of triglyceride fatty acids (TGFA) favoring storage over oxidation may play a central role in the development of some forms of obesity. it is hypothesized that defects in the oxidation and storage of lipid fuel within skeletal muscle play an important role in the development and maintenance of the obese state by shunting dietary fat towards storage in adipose tissue. The goal of the research projects proposed is to test this hypothesis by following the metabolic fate of lipid fuels in skeletal muscle from lean and obese rats. In addition the enzyme systems responsible for the metabolism of fatty acids within skeletal muscle will be examined in detail. Over the last 20 years radioactive tracer studies have shed important new light on the abnormalities of carbohydrate metabolism which are present in obesity and type II diabetes. Studies of TGFA metabolism however have lagged far behind, and yet may provide important insights into the mechanisms which underlie the development and maintenance of obesity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK048520-03
Application #
6239161
Study Section
Project Start
1997-01-01
Project End
1997-12-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Lee, J Scott; Wang, Ruth X; Alexeev, Erica E et al. (2018) Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function. J Biol Chem 293:6039-6051
Choi, Soo Youn; Lim, Sun Woo; Salimi, Shabnam et al. (2018) Tonicity-Responsive Enhancer-Binding Protein Mediates Hyperglycemia-Induced Inflammation and Vascular and Renal Injury. J Am Soc Nephrol 29:492-504
Bjornstad, Petter; Pyle, Laura; Cherney, David Z I et al. (2018) Plasma biomarkers improve prediction of diabetic kidney disease in adults with type 1 diabetes over a 12-year follow-up: CACTI study. Nephrol Dial Transplant 33:1189-1196
Iwamoto, Sean; Saxon, David; Tsai, Adam et al. (2018) Effects of Education and Experience on Primary Care Providers' Perspectives of Obesity Treatments during a Pragmatic Trial. Obesity (Silver Spring) 26:1532-1538
Wang, Xiaoxin X; Wang, Dong; Luo, Yuhuan et al. (2018) FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity. J Am Soc Nephrol 29:118-137
Scalzo, Rebecca L; Bauer, Timothy A; Harrall, Kylie et al. (2018) Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes. Diabetol Metab Syndr 10:7
Montasser, May E; O'Hare, Elizabeth A; Wang, Xiaochun et al. (2018) An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels. Circulation 138:1343-1355
Rozance, Paul J; Zastoupil, Laura; Wesolowski, Stephanie R et al. (2018) Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol 596:67-82
Abbate, Lauren M; Jeffreys, Amy S; Coffman, Cynthia J et al. (2018) Demographic and Clinical Factors Associated With Nonsurgical Osteoarthritis Treatment Among Patients in Outpatient Clinics. Arthritis Care Res (Hoboken) 70:1141-1149
Cara-Fuentes, Gabriel; Lanaspa, Miguel A; Garcia, Gabriela E et al. (2018) Urinary CD80: a biomarker for a favorable response to corticosteroids in minimal change disease. Pediatr Nephrol 33:1101-1103

Showing the most recent 10 out of 756 publications