Advances in perinatal care have allowed for the survival of an increasingly larger population of neonates weighing less than 1000 g, referred to as extremely-low-birthweight (ELBW) infants. Because of limited supplies of endogenous energy reserves, the ELBW infant is extremely vulnerable to inadequate nutritional intake. The optimal strategy for supplying nutrition to these infants is poorly defined because of limited information on their substrate metabolism. Using common parenteral feeding regimens, we propose to study protein kinetics and the effects of the quality of infused energy on protein metabolism in the ELBW infant in the first 48 hours of life using stable isotope methodology combined with indirect calorimetry. Stable isotopic tracers of leucine, glucose and glycerol will be infused simultaneously to determine protein synthesis and oxidation, glucose production and utilization, and the rate of lipolysis. As part of this work, validation of a neonatal indirect calorimeter designed specifically for use in premature ventilated and non-ventilated infants will be completed. A neonatal activity monitor is also being developed to use as calorimetry for further refinement of metabolic data collection.

Project Start
1998-01-01
Project End
1998-12-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Kuwabara, Masanari; Hisatome, Ichiro; Roncal-Jimenez, Carlos A et al. (2018) Correction: Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study. PLoS One 13:e0197941
Espeland, Mark A; Carmichael, Owen; Hayden, Kathleen et al. (2018) Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci 73:484-491
Gadek, Katherine E; Wang, Hong; Hall, Monica N et al. (2018) Striated muscle gene therapy for the treatment of lipoprotein lipase deficiency. PLoS One 13:e0190963
Foright, R M; Presby, D M; Sherk, V D et al. (2018) Is regular exercise an effective strategy for weight loss maintenance? Physiol Behav 188:86-93
Hurtado-Arestegui, Abdias; Plata-Cornejo, Raul; Cornejo, Arturo et al. (2018) Higher prevalence of unrecognized kidney disease at high altitude. J Nephrol 31:263-269
Musci, Robert V; Hamilton, Karyn L; Miller, Benjamin F (2018) Targeting mitochondrial function and proteostasis to mitigate dynapenia. Eur J Appl Physiol 118:1-9
Reusch, Jane E B; Kumar, T Rajendra; Regensteiner, Judith G et al. (2018) Identifying the Critical Gaps in Research on Sex Differences in Metabolism Across the Life Span. Endocrinology 159:9-19
Geng, Xin; Irvin, Marguerite R; Hidalgo, Bertha et al. (2018) An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort. J Lipid Res 59:722-729
Schenkman, Margaret; Moore, Charity G; Kohrt, Wendy M et al. (2018) Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial. JAMA Neurol 75:219-226
Stojanovi?, Danijela; B?žková, Petra; Mukamal, Kenneth J et al. (2018) Soluble Inflammatory Markers and Risk of Incident Fractures in Older Adults: The Cardiovascular Health Study. J Bone Miner Res 33:221-228

Showing the most recent 10 out of 756 publications