Abstract

The broad goal of the Colorado Clinical Nutrition Research Unit (CNRU) is to better utilize our clinical and basic science nutrition research expertise in order to make nutrition t more reliable and effective component of future health care. Reflecting the strength of our research base, the theme will be nutrient utilization with three focus areas: obesity & diabetes; developmental aspects of nutrient utilization; and micronutrient utilization and function. Each focus area will include a continuum of research from the patient or healthy subject ot the subcellular and molecular levels. The Colorado CNRU consists of an Administrative Core and 4 Scientific Core Laboratories - Energy Balance, Mass Spectrometry, Metabolic, Cellular & Molecular Biology. Included within the Administrative Core are a Pilot & Feasibility Program, a New Investigator Award, a recruiter, a statistician, and a communications expert. The Colorado CNRU will greatly strengthen existing nutrition research programs by promoting collaboration, stimulating new research directions, providing otherwise unavailable cost-effective measurements and expertise, and providing an outstanding environment for trainees and young investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK048520-05
Application #
2856774
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hubbard, Van S
Project Start
1995-03-15
Project End
1999-12-31
Budget Start
1999-04-15
Budget End
1999-12-31
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Lee, J Scott; Wang, Ruth X; Alexeev, Erica E et al. (2018) Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function. J Biol Chem 293:6039-6051
Choi, Soo Youn; Lim, Sun Woo; Salimi, Shabnam et al. (2018) Tonicity-Responsive Enhancer-Binding Protein Mediates Hyperglycemia-Induced Inflammation and Vascular and Renal Injury. J Am Soc Nephrol 29:492-504
Bjornstad, Petter; Pyle, Laura; Cherney, David Z I et al. (2018) Plasma biomarkers improve prediction of diabetic kidney disease in adults with type 1 diabetes over a 12-year follow-up: CACTI study. Nephrol Dial Transplant 33:1189-1196
Iwamoto, Sean; Saxon, David; Tsai, Adam et al. (2018) Effects of Education and Experience on Primary Care Providers' Perspectives of Obesity Treatments during a Pragmatic Trial. Obesity (Silver Spring) 26:1532-1538
Wang, Xiaoxin X; Wang, Dong; Luo, Yuhuan et al. (2018) FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity. J Am Soc Nephrol 29:118-137
Scalzo, Rebecca L; Bauer, Timothy A; Harrall, Kylie et al. (2018) Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes. Diabetol Metab Syndr 10:7
Montasser, May E; O'Hare, Elizabeth A; Wang, Xiaochun et al. (2018) An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels. Circulation 138:1343-1355
Rozance, Paul J; Zastoupil, Laura; Wesolowski, Stephanie R et al. (2018) Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol 596:67-82
Abbate, Lauren M; Jeffreys, Amy S; Coffman, Cynthia J et al. (2018) Demographic and Clinical Factors Associated With Nonsurgical Osteoarthritis Treatment Among Patients in Outpatient Clinics. Arthritis Care Res (Hoboken) 70:1141-1149
Cara-Fuentes, Gabriel; Lanaspa, Miguel A; Garcia, Gabriela E et al. (2018) Urinary CD80: a biomarker for a favorable response to corticosteroids in minimal change disease. Pediatr Nephrol 33:1101-1103

Showing the most recent 10 out of 756 publications