Abstract

Obesity is a major public health problem in this country. Currently the mechanisms which underlie the development of obesity are obscure. While a complex interaction between nutrient intake, energy expenditure and fuel metabolism exists, evidence in humans and laboratory animals suggests that abnormal partitioning of triglyceride fatty acids (TGFA) favoring storage over oxidation may play a central role in the development of some forms of obesity. it is hypothesized that defects in the oxidation and storage of lipid fuel within skeletal muscle play an important role in the development and maintenance of the obese state by shunting dietary fat towards storage in adipose tissue. The goal of the research projects proposed is to test this hypothesis by following the metabolic fate of lipid fuels in skeletal muscle from lean and obese rats. In addition the enzyme systems responsible for the metabolism of fatty acids within skeletal muscle will be examined in detail. Over the last 20 years radioactive tracer studies have shed important new light on the abnormalities of carbohydrate metabolism which are present in obesity and type II diabetes. Studies of TGFA metabolism however have lagged far behind, and yet may provide important insights into the mechanisms which underlie the development and maintenance of obesity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK048520-05
Application #
6105625
Study Section
Project Start
1999-04-15
Project End
1999-12-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Rozance, Paul J; Zastoupil, Laura; Wesolowski, Stephanie R et al. (2018) Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol 596:67-82
Abbate, Lauren M; Jeffreys, Amy S; Coffman, Cynthia J et al. (2018) Demographic and Clinical Factors Associated With Nonsurgical Osteoarthritis Treatment Among Patients in Outpatient Clinics. Arthritis Care Res (Hoboken) 70:1141-1149
Montasser, May E; O'Hare, Elizabeth A; Wang, Xiaochun et al. (2018) An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels. Circulation 138:1343-1355
Rudolph, Michael C; Jackman, Matthew R; Presby, David M et al. (2018) Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance. Diabetes 67:651-661
Gregory, Mark A; Nemkov, Travis; Reisz, Julie A et al. (2018) Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia. Exp Hematol 58:52-58
Cara-Fuentes, Gabriel; Lanaspa, Miguel A; Garcia, Gabriela E et al. (2018) Urinary CD80: a biomarker for a favorable response to corticosteroids in minimal change disease. Pediatr Nephrol 33:1101-1103
Ostendorf, Danielle M; Lyden, Kate; Pan, Zhaoxing et al. (2018) Objectively Measured Physical Activity and Sedentary Behavior in Successful Weight Loss Maintainers. Obesity (Silver Spring) 26:53-60
Bruce, Kimberley D; Gorkhali, Sachi; Given, Katherine et al. (2018) Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination. Front Mol Neurosci 11:57
Allshouse, Amanda A; Santoro, Nanette; Green, Robin et al. (2018) Religiosity and faith in relation to time to metabolic syndrome for Hispanic women in a multiethnic cohort of women-Findings from the Study of Women's Health Across the Nation (SWAN). Maturitas 112:18-23
Gavin, Kathleen M; Kohrt, Wendy M; Klemm, Dwight J et al. (2018) Modulation of Energy Expenditure by Estrogens and Exercise in Women. Exerc Sport Sci Rev 46:232-239

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