Abstract

As described above, we have spent the last few months engaging our research base in developing a new organizational structure for nutrition/obesity research and for the Colorado NORC. Our previous focus on nutrient utilization was a good fit for our original research base but the breadth of our current research base led us to revise our focus. The depth and breadth of our research base now allows us to take a broader approach to nutrition/obesity. Our investigators are conducting leading edge basic, clinical, and community research in nutrition and obesity and obesity-related comorbidities. They conduct research with children, adults, and seniors. We did not want to have a narrow focus for the NORC. Thus, we identified our focus as promoting translational research in nutrition and obesity. We propose to organize the NORC around the following 6 areas: 1. Regulation of food intake 2. Weight Management 3. Energy Metabolism in Health &Disease 4. Obesity and Metabolic Dysregulation 5. Maternal-Fetal Origins of Chronic Disease 6. Obesity Cell Biology

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK048520-16
Application #
8016436
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (M2))
Project Start
2010-08-01
Project End
2015-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
16
Fiscal Year
2010
Total Cost
$617,396
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Beli, Eleni; Yan, Yuanqing; Moldovan, Leni et al. (2018) Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice. Diabetes 67:1867-1879
Mintz, Michael; Khair, Shanawaj; Grewal, Suman et al. (2018) Longitudinal microbiome analysis of single donor fecal microbiota transplantation in patients with recurrent Clostridium difficile infection and/or ulcerative colitis. PLoS One 13:e0190997
Lee, Dustin M; Battson, Micah L; Jarrell, Dillon K et al. (2018) SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice. Cardiovasc Diabetol 17:62
Alexeev, Erica E; Lanis, Jordi M; Kao, Daniel J et al. (2018) Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor. Am J Pathol 188:1183-1194
Hildreth, Kerry L; Ozemek, Cemal; Kohrt, Wendy M et al. (2018) Vascular dysfunction across the stages of the menopausal transition is associated with menopausal symptoms and quality of life. Menopause 25:1011-1019
Beune, Irene M; Bloomfield, Frank H; Ganzevoort, Wessel et al. (2018) Consensus Based Definition of Growth Restriction in the Newborn. J Pediatr 196:71-76.e1
Keller, A C; Knaub, L A; Scalzo, R L et al. (2018) Sepiapterin Improves Vascular Reactivity and Insulin-Stimulated Glucose in Wistar Rats. Oxid Med Cell Longev 2018:7363485
Creasy, Seth A; Rynders, Corey A; Bergouignan, Audrey et al. (2018) Free-Living Responses in Energy Balance to Short-Term Overfeeding in Adults Differing in Propensity for Obesity. Obesity (Silver Spring) 26:696-702
Lanaspa, Miguel A; Kuwabara, Masanari; Andres-Hernando, Ana et al. (2018) High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism. Proc Natl Acad Sci U S A 115:3138-3143
Bergman, Bryan C; Perreault, Leigh; Strauss, Allison et al. (2018) Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans. Am J Physiol Endocrinol Metab 314:E152-E164

Showing the most recent 10 out of 756 publications