Abstract

The overall theme of the Metabolic Core lab is to support investigation of insulin resistance, obesity, and inflammation from a cellular/molecular perspective. The Metabolic Core provides consultation and analysis of insulin signaling, hormone assays, qPCR, insulin clamping (mice, rats), and cell based assays of cytokines and adipokines tailored to the investigators needs. Over the last grant period the Metabolic Core has developed expertise in multiplex based cytokine analysis. Most recently the Metabolic Core received NIH funding to purchase a Seahorse XF24-3 extracellular flux analyzer to allow us to begin to interrogate mitochondrial function.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK048520-20
Application #
8730600
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
20
Fiscal Year
2014
Total Cost
$218,149
Indirect Cost
$71,819

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Stojanovi?, Danijela; B?žková, Petra; Mukamal, Kenneth J et al. (2018) Soluble Inflammatory Markers and Risk of Incident Fractures in Older Adults: The Cardiovascular Health Study. J Bone Miner Res 33:221-228
Melanson, Edward L; Swibas, Tracy; Kohrt, Wendy M et al. (2018) Validation of the doubly labeled water method using off-axis integrated cavity output spectroscopy and isotope ratio mass spectrometry. Am J Physiol Endocrinol Metab 314:E124-E130
Schenkman, Margaret; Moore, Charity G; Kohrt, Wendy M et al. (2018) Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial. JAMA Neurol 75:219-226
Kriska, Andrea; El Ghormli, Laure; Copeland, Kenneth C et al. (2018) Impact of lifestyle behavior change on glycemic control in youth with type 2 diabetes. Pediatr Diabetes 19:36-44
Portz, Jennifer Dickman; Vehovec, Anton; Dolansky, Mary A et al. (2018) The Development and Acceptability of a Mobile Application for Tracking Symptoms of Heart Failure Among Older Adults. Telemed J E Health 24:161-165
Painter, Stefanie Lynn; Ahmed, Rezwan; Kushner, Robert F et al. (2018) Expert Coaching in Weight Loss: Retrospective Analysis. J Med Internet Res 20:e92
Lee, J Scott; Wang, Ruth X; Alexeev, Erica E et al. (2018) Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function. J Biol Chem 293:6039-6051
Choi, Soo Youn; Lim, Sun Woo; Salimi, Shabnam et al. (2018) Tonicity-Responsive Enhancer-Binding Protein Mediates Hyperglycemia-Induced Inflammation and Vascular and Renal Injury. J Am Soc Nephrol 29:492-504
Bjornstad, Petter; Pyle, Laura; Cherney, David Z I et al. (2018) Plasma biomarkers improve prediction of diabetic kidney disease in adults with type 1 diabetes over a 12-year follow-up: CACTI study. Nephrol Dial Transplant 33:1189-1196
Iwamoto, Sean; Saxon, David; Tsai, Adam et al. (2018) Effects of Education and Experience on Primary Care Providers' Perspectives of Obesity Treatments during a Pragmatic Trial. Obesity (Silver Spring) 26:1532-1538

Showing the most recent 10 out of 756 publications