The University of Southern California Research Center for Liver Diseases, funded since 1995, has the goal of fostering and facilitating interdisciplinary research in liver and digestive disease. The Center has 41 members and 17 affiliated members. The Biomedical Research Base consists of four major Themes supported by 57 peer-reviewed grants totaling $10.8 million in annual direct costs. These Themes include: a) viral hepatitis and liver cancer;b) liver injury;c) cell biology, signal transduction, and transport;d) metabolism and gene expression. Four core facilities support this Research Base: 1) Administrative Core which oversees the operations and budget of the Center;the Center Director, Associate Director, Executive Committee, Administrator and External Advisory Board oversee the utilization of the cores, the pilot/feasibility program, and the enrichment program (seminar series and annual symposium);a Mathematical-Analysis Modeling and Image Processing Subcore is available to Center members through the Administrative Core;2) Molecular Biology Core which is divided into three components: a Central Core which provides access to teaching and equipment as well as specialized techniques, a Proteomic Subcore, and a Microarray Subcore;3) Cell Biology Core which is divided into a Subcellular Organelle Subcore, which provides cell fractionation, specialized preparations (domaine-enriched vesicles, perfused liver), and access to equipment, and a Confocal Microscopy Subcore which provides imaging of live and fixed cells using various platforms including a new ancillary multiphoton confocal microscope;4) Cell Culture Core which provides isolated and primary cultured rat, mouse and human hepatocytes and various cell lines. The Center supports Pilot Feasibility projects in diverse areas related to the Themes of the Research Base. Current projects including a) studies to define the mechanism of entry and exit and intracellular trafficking of adenovirus in hepatocytes;b) the characterization of tight junctional claudins in intestinal epithelia and their role in regulation of paracellular permeability;c) the mechanism of endotoxin-induced stabilization of TNF mRNA: role of methylation of stabilizing protein;d) examination of the structure-function of the intestinal transporter, PepT1. The USC Research Center for Liver Diseases remains dedicated to attracting, promoting, and supporting research aimed at understanding, preventing, and treating liver and digestive diseases.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (M1))
Program Officer
Podskalny, Judith M,
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Southern California
Internal Medicine/Medicine
Schools of Medicine
Los Angeles
United States
Zip Code
Ju, Yaping; Janga, Srikanth Reddy; Klinngam, Wannita et al. (2018) NOD and NOR mice exhibit comparable development of lacrimal gland secretory dysfunction but NOD mice have more severe autoimmune dacryoadenitis. Exp Eye Res 176:243-251
Peddi, Santosh; Pan, Xiaoli; MacKay, John Andrew (2018) Intracellular Delivery of Rapamycin From FKBP Elastin-Like Polypeptides Is Consistent With Macropinocytosis. Front Pharmacol 9:1184
Zhou, Beiyun; Flodby, Per; Luo, Jiao et al. (2018) Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest 128:970-984
Khanova, Elena; Wu, Raymond; Wang, Wen et al. (2018) Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. Hepatology 67:1737-1753
Zhang, Chunying; Niu, Chao; Yang, Kevin et al. (2018) Human esophageal myofibroblast secretion of bone morphogenetic proteins and GREMLIN1 and paracrine regulation of squamous epithelial growth. Sci Rep 8:12354
Tsai, Yuan-Li; Ha, Dat P; Zhao, He et al. (2018) Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-? signaling. Proc Natl Acad Sci U S A 115:E4245-E4254
Chen, Jingwen; Lam, Albert T; Zhang, Yong (2018) A macrodomain-linked immunosorbent assay (MLISA) for mono-ADP-ribosyltransferases. Anal Biochem 543:132-139
Chang, Huiyi H; Yeh, Jih-Chao; Ichiyama, Ronaldo M et al. (2018) Mapping and neuromodulation of lower urinary tract function using spinal cord stimulation in female rats. Exp Neurol 305:26-32
Chen, Chien-Yu; Chen, Jingyu; He, Lina et al. (2018) PTEN: Tumor Suppressor and Metabolic Regulator. Front Endocrinol (Lausanne) 9:338
Nakamura, Brooke N; Glazier, Alison; Kattah, Michael G et al. (2018) A20 regulates canonical wnt-signaling through an interaction with RIPK4. PLoS One 13:e0195893

Showing the most recent 10 out of 449 publications