Abstract

The Cell Culture Core has supported and will continue to support the Center in several ways, all with the specific goal of fostering digestive disease research in the Center. Through enhancing the quality of cell culture techniques used by Center investigators, the Cell Culture Core will be an important vehicle for collaborative digestive disease research due to availability of centralized services and reagents. The purpose of the Core are the following: to provide and maintain primary and organotropic cell cultures; to provide and maintain a repository for established malignant cell lines and adenoviral vectors, and to train Center investigators and their laboratory personnel in cell culture techniques.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK050306-06
Application #
6646745
Study Section
Special Emphasis Panel (ZDK1)
Project Start
2002-07-15
Project End
2007-06-30
Budget Start
Budget End
Support Year
6
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

DeLong, Jonathan H; Hall, Aisling O'Hara; Konradt, Christoph et al. (2018) Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1. J Immunol 200:1761-1770
Williams, Bianca; Correnti, Jason; Oranu, Amanke et al. (2018) A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis. FASEB J 32:130-142
Karakasheva, Tatiana A; Lin, Eric W; Tang, Qiaosi et al. (2018) IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment. Cancer Res 78:4957-4970
Bengsch, Bertram; Ohtani, Takuya; Herati, Ramin Sedaghat et al. (2018) Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns. J Immunol Methods 453:3-10
Moreira, Leticia; Bakir, Basil; Chatterji, Priya et al. (2018) Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol 5:289-298
Das, Koushik K; Heeg, Steffen; Pitarresi, Jason R et al. (2018) ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis. Dev Dyn 247:854-866
Kasagi, Yuta; Chandramouleeswaran, Prasanna M; Whelan, Kelly A et al. (2018) The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes. Cell Mol Gastroenterol Hepatol 5:333-352
Chatterji, Priya; Hamilton, Kathryn E; Liang, Shun et al. (2018) The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine. Genes Dev 32:1020-1034
Klingberg, Franco; Chau, Grace; Walraven, Marielle et al. (2018) The fibronectin ED-A domain enhances recruitment of latent TGF-?-binding protein-1 to the fibroblast matrix. J Cell Sci 131:
Ban, Ehsan; Franklin, J Matthew; Nam, Sungmin et al. (2018) Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces. Biophys J 114:450-461

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