The mission ofthe Minnesota Obesity Center is to find ways to prevent weight gain, and the onset of obesity and complications of obesity. Obesity is a major source of illness and death, and is the most common nutritional ailment in the United States. Little is known about effective measures to prevent obesity. Obese individuals can more easily lose weight than maintain the loss. Prevention of initial weight gain should be emphasized, and failing that, prevention of regain after weight loss. Four goals are established: 1) find the underlying problems that lead to obesity, 2) identify behaviors that lead to obesity and find ways to help change those behaviors, 3) seek means to prevent obesity-related co-morbidities and 4) determine public health and public policy measures that will reduce the frequency and severity of obesity. The Center will promote studies directed at these aims by: assisting principal investigators in conducting relevant research by providing resources through the core system;stimulating new interest and collaborations in research into obesity, eating disorders and energy metabolism;supporting new research in these areas related to obesity; and supporting education in obesity and eating disorders in the academic and public communities. The research base consists of 75 investigators with 137 funded projects generating over 34 million dollars per year in grant support. Five cores are proposed: 1) Administration will provide vision, leadership, and oversight of other core activities, 2) Molecular and Cellular Basis of Obesity Core will assist investigators pursuing research projects on the fundamental mechanisms that control or affect adiposity and energy metabolism, 3) Disordered Eating Assessment Core will assist in the assessment of disordered eating and other psychopathology, and the development of interventions for such disordered eating, 4) Epidemiology and Intervention Core is to make high quality services for epidemiological and behavioral intervention studies available, 5) Metabolic Studies Core Laboratory will provide access to established and state-of-the-art methods for studying energy metabolism and nutrient partitioning at the whole body level. Resources for oilot/feasibilitv proiects and an educational program will be established.

Public Health Relevance

The Minnesota Obesity Center's mission is to find ways to prevent weight gain, obesity and the complications of obesity. Obesity is a major source of illness and death, and is the most important public health problem in the U.S. Despite its prevalence, little is known about effective measures to prevent obesity and its attendant complications. The Center will support work focused on prevention of initial weight gain, prevention of regain after weight loss, and prevention of obesity complications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK050456-19
Application #
8640139
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Evans, Mary
Project Start
1997-09-01
Project End
2016-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
19
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Nutrition
Type
Earth Sciences/Resources
DUNS #
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Xu, Ming; Pirtskhalava, Tamar; Farr, Joshua N et al. (2018) Senolytics improve physical function and increase lifespan in old age. Nat Med 24:1246-1256
Gross, Amy C; Kaizer, Alexander M; Ryder, Justin R et al. (2018) Relationships of Anxiety and Depression with Cardiovascular Health in Youth with Normal Weight to Severe Obesity. J Pediatr 199:85-91
Chung, Jin Ook; Koutsari, Christina; Blachnio-Zablieska, Agnieszka Urszula et al. (2018) Effects of meal ingestion on intramyocellular ceramide concentrations and fractional de novo synthesis in humans. Am J Physiol Endocrinol Metab 314:E105-E114
Fyfe-Johnson, Amber L; Ryder, Justin R; Alonso, Alvaro et al. (2018) Ideal Cardiovascular Health and Adiposity: Implications in Youth. J Am Heart Assoc 7:
Reid, Brie M; Harbin, Michelle M; Arend, Jessica L et al. (2018) Early Life Adversity with Height Stunting Is Associated with Cardiometabolic Risk in Adolescents Independent of Body Mass Index. J Pediatr 202:143-149
Smith, Kathryn E; Mason, Tyler B; Crosby, Ross D et al. (2018) State and trait positive and negative affectivity in relation to restraint intention and binge eating among adults with obesity. Appetite 120:327-334
McGee-Lawrence, Meghan E; Pierce, Jessica L; Yu, Kanglun et al. (2018) Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity. J Cell Physiol 233:2671-2680
Pfister, Katie M; Zhang, Lei; Miller, Neely C et al. (2018) Early body composition changes are associated with neurodevelopmental and metabolic outcomes at 4 years of age in very preterm infants. Pediatr Res 84:713-718
Roelfsema, Ferdinand; Yang, Rebecca J; Veldhuis, Johannes D (2018) Differential Effects of Estradiol and Progesterone on Cardiovascular Risk Factors in Postmenopausal Women. J Endocr Soc 2:794-805
Halper, Alyssa; Sanchez, Belen; Hodges, James S et al. (2018) Bone mineral density and body composition in children with congenital adrenal hyperplasia. Clin Endocrinol (Oxf) 88:813-819

Showing the most recent 10 out of 717 publications