This application is for continued support of the Digestive Diseases Research Core Center (DDRCC) at Washington University St. Louis, which is the central institutional resource for investigators interested in the regulatory mechanisms and pathophysiology of the gastrointestinal tract and liver. The central focus of investigation is on inflammatory bowel diseases and its complications. However, we take a broad view of relevant research and will continue to support research on basic biological processes relevant to inflammatory bowel diseases, even if the systems being studied are not immediately applicable to inflammatory bowel diseases. The DDRCC supports an outstanding Research Base consisting of 62 Investigators in 10 departments with research grants totaling $17.5 million dollars (47% NIDDK funding). The DDRCC sustains its strong Research Base by actively supporting career development of new investigators through its Pilot/Feasibility Program. Nine former and four current Pilot/Feasibility awardees currently contribute to the Research Base. Four research core facilities (Murine Models/Gnotobiotic Core, Morphology Core, Functional Genomics Core and Proteomics Core) play a central role in promoting collaboration and synergy between individuals. They pool resources to provide services and expertise that would be cost and time- prohibitive to develop de novo, and maintain. To facilitate the conduct of clinical and translational research in inflammatory bowel diseases, the Clinical Component of the DDRCC consists of a Tissue Procurement Facility archives clinical samples linked to longitudinal clinical information ( >1,100 patients with inflammatory bowel diseases recruited in three years) and promotes new collaborative and synergistic interactions between basic researchers and clinicians. The DDRCC Clinical Component and Research Core facilities are integrated within the framework of the Clinical Translational Science Award - sponsored biomedical informatics infrastructure. By collecting clinical samples and linking them to integrated clinical information collected in focused longitudinal studies and research data generated from these samples by the DDRCC Research Core Facilities, the DDRCC is building a comprehensive multidimensional discovery platform from which investigators can launch further hypothesis-driven studies on inflammatory bowel disease pathogenesis.

Public Health Relevance

The Digestive Diseases Research Core Center at Washington University -St. Louis serves as a central institutional resource for investigators interested in research on inflammatory bowel diseases. It provides services and pools resources to help researchers address questions on how inflammatory bowel diseases arise and how we can treat these diseases

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK052574-15
Application #
8574503
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (M1))
Program Officer
Podskalny, Judith M,
Project Start
2000-03-01
Project End
2014-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
15
Fiscal Year
2014
Total Cost
$1,009,379
Indirect Cost
$345,314
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Feng, Jing; Luo, Jialie; Yang, Pu et al. (2018) Piezo2 channel-Merkel cell signaling modulates the conversion of touch to itch. Science 360:530-533
Gathungu, Grace; Zhang, Yuanhao; Tian, Xinyu et al. (2018) Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal Crohn's disease. World J Gastroenterol 24:623-630
Zhang, Daoxiang; Li, Lin; Jiang, Hongmei et al. (2018) Tumor-Stroma IL1?-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, and Poor Prognosis in Pancreatic Cancer. Cancer Res 78:1700-1712
Sullender, Meagan E; Baldridge, Megan T (2018) Norovirus interactions with the commensal microbiota. PLoS Pathog 14:e1007183
Eberth, Jan M; Josey, Michele J; Mobley, Lee R et al. (2018) Who Performs Colonoscopy? Workforce Trends Over Space and Time. J Rural Health 34:138-147
Luo, Jialie; Feng, Jing; Yu, Guang et al. (2018) Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch. J Allergy Clin Immunol 141:608-619.e7
Tarr, Gillian A M; Oltean, Hanna N; Phipps, Amanda I et al. (2018) Strength of the association between antibiotic use and hemolytic uremic syndrome following Escherichia coli O157:H7 infection varies with case definition. Int J Med Microbiol 308:921-926
Brenot, Audrey; Knolhoff, Brett L; DeNardo, David G et al. (2018) SNAIL1 action in tumor cells influences macrophage polarization and metastasis in breast cancer through altered GM-CSF secretion. Oncogenesis 7:32
Kumar, Pardeep; Kuhlmann, F Matthew; Chakraborty, Subhra et al. (2018) Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity. J Clin Invest 128:3298-3311
Baumann-Dudenhoeffer, Aimee M; D'Souza, Alaric W; Tarr, Phillip I et al. (2018) Infant diet and maternal gestational weight gain predict early metabolic maturation of gut microbiomes. Nat Med 24:1822-1829

Showing the most recent 10 out of 899 publications