The Washington University DDRCC is integrated with the NIH's Clinical Translational Science Award (CTSA) sponsored Washington University Institute of Clinical Translational Sciences (ICTS), primarily through the Clinical Component ofthe DDRCC and the ICTS Centerfor Biomedical Informatics. The DDRCC Clinical Component is primarily focused on providing investigators with access to clinical samples for digestive diseases related research. The collection and maintenance of clinical samples linked to longitudinal clinical information in a manner that is responsive to our DDRCC investigators, requires a high level of clinical expertise in accurately phenotyping the patient subjects and a high level of stringent oversight in collecting clinical samples. For this reason, organization of tissue procurement at this institution has moved away from a single monolithic institutional unit attempting to collect a broad array of clinical samples from patients with many different diseases. Instead, tissue procurement is being conducted by smaller disease focused units, such as the DDRCC sponsored facility, that are linked to each other by a common biomedical informatics platforms (Tissue Suite and ClinPortal) developed and maintained by the CTSA-sponsored Center for Biomedical Informatics. Furthermore, the data output from two of the Research Core Facilities, the Functional Genomics Core and the Proteomics Core are in the process of being uploaded to databases (Profile DB) maintained by the ICTS Center for Biomedical Informatics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK052574-15
Application #
8574506
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
15
Fiscal Year
2014
Total Cost
$452,726
Indirect Cost
$154,881
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Ingle, Harshad; Peterson, Stefan T; Baldridge, Megan T (2018) Distinct Effects of Type I and III Interferons on Enteric Viruses. Viruses 10:
Wang, Xuanchuan; Xu, Min; Jia, Jianluo et al. (2018) CD47 blockade reduces ischemia/reperfusion injury in donation after cardiac death rat kidney transplantation. Am J Transplant 18:843-854
Platt, Derek J; Smith, Amber M; Arora, Nitin et al. (2018) Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice. Sci Transl Med 10:
Biddy, Brent A; Kong, Wenjun; Kamimoto, Kenji et al. (2018) Single-cell mapping of lineage and identity in direct reprogramming. Nature 564:219-224
Patel, A; Hasak, S; Nix, B D et al. (2018) Genetic risk factors for perception of symptoms in GERD: an observational cohort study. Aliment Pharmacol Ther 47:289-297
Strubberg, Ashlee M; Veronese Paniagua, Daniel A; Zhao, Tingting et al. (2018) The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells. Stem Cell Reports 11:410-424
Mayer, Allyson L; Zhang, Yiming; Feng, Emily H et al. (2018) Enhanced Hepatic PPAR? Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice. Endocrinology 159:2110-2126
Hibberd, Timothy J; Feng, Jing; Luo, Jialie et al. (2018) Optogenetic Induction of Colonic Motility in Mice. Gastroenterology 155:514-528.e6
Osaki, Luciana H; Bockerstett, Kevin A; Wong, Chun Fung et al. (2018) Interferon-? directly induces gastric epithelial cell death and is required for progression to metaplasia. J Pathol :
Wardill, Hannah R; Van Sebille, Ysabella Z A; Ciorba, Matthew A et al. (2018) Prophylactic probiotics for cancer therapy-induced diarrhoea: a meta-analysis. Curr Opin Support Palliat Care 12:187-197

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