The overarching goal of the Washington University Digestive Disease Research Core Center, (WU-DDRCC) is to assist investigators exploring the foundations of host-environment interactions in the pathophysiology of digestive diseases. The WU-DDRCC seeks to advance the health of patients with digestive diseases by supporting enabling technology and promoting the basic and translational research interests of its 49 Full + 11 Associate members, he DDRCC promotes the expertise and interests of the Research Base in a comprehensive program that is strategically aligned with the distinguishing institutional strengths in human genetics and the microbiome. The Center is justified by the needs of its members and has adapted to provide core support and enabling technology that expands members' research capacity through core laboratories that provide training, technical support and a unique centralized resource for organization of clinical metadata and biospecimens. In addition, the Center provides a Pilot/Feasibility Program that offers start up and support to junior investigators wishing to pursue digestive disease research. Finally, the Center has a scientific Enrichment Program that supports lectures and workshops by visiting scientists and promotes interactions and collaborations among the members. The WU-DDRCC includes 49 Full members with overall TDCs of $23.8M. The Research Base includes investigators whose interests span three major areas, specifically (1) Host-microbial interactions/inflammations/mucosal immunity; (2) Stem cell biology/development/epithelial renewal/cancer biology; (3) Nutrient transport/metabolism/ signaling. The research interests of the Full members/Research Base are approximately equally represented among these three broad categories while simultaneously maintaining a strong focus on host-environmental factors in digestive disease. The WU-DDRCC includes four Cores, including an Administrative and Resource Access Core (ARAC), a Biobank Core, a Murine Models Core and an Advanced Imaging and Tissue Analysis Core. In addition, the WU-DDRCC has an active Enrichment Program and a Pilot/Feasibility Program that has supported and nurtured new investigators as they transition to scientific independence.

Public Health Relevance

Research supported through the WU DDRCC has and will continue to have a profound impact on understanding the pathophysiology of digestive disease and the role of host-environment interactions. The WU DDRCC also promotes scientific collaboration and synergies that ultimately will identify new therapeutic opportunities with the potential for rapid translation into clinical trials for patients with digestive diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK052574-20
Application #
9605770
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Perrin, Peter J
Project Start
2000-12-01
Project End
2019-11-30
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
20
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Song, Wilbur M; Joshita, Satoru; Zhou, Yingyue et al. (2018) Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism. J Exp Med 215:745-760
Bockerstett, Kevin A; Osaki, Luciana H; Petersen, Christine P et al. (2018) Interleukin-17A Promotes Parietal Cell Atrophy by Inducing Apoptosis. Cell Mol Gastroenterol Hepatol 5:678-690.e1
Willet, Spencer G; Lewis, Mark A; Miao, Zhi-Feng et al. (2018) Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis. EMBO J 37:
Bando, Jennifer K; Gilfillan, Susan; Song, Christina et al. (2018) The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells. Immunity 48:1208-1219.e4
Gathungu, Grace; Zhang, Yuanhao; Tian, Xinyu et al. (2018) Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal Crohn's disease. World J Gastroenterol 24:623-630
Feng, Jing; Luo, Jialie; Yang, Pu et al. (2018) Piezo2 channel-Merkel cell signaling modulates the conversion of touch to itch. Science 360:530-533
Zhang, Daoxiang; Li, Lin; Jiang, Hongmei et al. (2018) Tumor-Stroma IL1?-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, and Poor Prognosis in Pancreatic Cancer. Cancer Res 78:1700-1712
Sullender, Meagan E; Baldridge, Megan T (2018) Norovirus interactions with the commensal microbiota. PLoS Pathog 14:e1007183
Eberth, Jan M; Josey, Michele J; Mobley, Lee R et al. (2018) Who Performs Colonoscopy? Workforce Trends Over Space and Time. J Rural Health 34:138-147
Luo, Jialie; Feng, Jing; Yu, Guang et al. (2018) Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch. J Allergy Clin Immunol 141:608-619.e7

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