(Administrative Core; Core 1) The Administrative Core provides oversight of the Center for Gene Therapy of Cystic Fibrosis, under the supervision of the Center Executive Committee and External Advisors. One major area of responsibility is largely administrative, including financial documentation and accountability for the Center's Pilot and Feasibility Program and its Cores, and oversight and documentation of external review of the Center overall. Three major governing bodies contribute to the review of various Center functions. The Pilot and Feasibility Committee oversees decisions regarding pilot funding, in conjunction with a Cystic Fibrosis Research and Development Program pilot program and an Institute for Clinical and Translational Science pilot program, with each pilot receiving two external reviews before a decision is made. The Executive Committee is the major decision- making body of the Center, and makes final judgments about the funding of new pilots and the renewal of ongoing pilots for a second year of funding. The External Advisory Committee provides direction to the Executive Committee, as does the College of Medicine leadership. A second major responsibility of this Core is to enrich CF-related scientific programs, and it does so through sustained membership and pilot recruitment efforts, scientific enrichment programs (seminar series, Center retreats, and less formal scientific working- group meetings), and assessment of the Center's Research Cores and their services (e.g., through investigator questionnaires and external review). Lastly, the Administrative Core acts as a conduit for research and services to both investigators outside the University of Iowa and the lay community (e.g., by maintaining the Center web site). In summary, the Administrative Core assists its members in making breakthroughs in CF research and molecular therapies by: 1) recruiting talented junior investigators into careers in CF research and mentoring them, through its pilot program and center activities; 2) assisting the Research Cores in providing efficient, high quality, and cost-effective services; and 3) providing forums for the exchange of new information and ideas among its members through its Enrichment Programs.
| Gray, Robert D; Hardisty, Gareth; Regan, Kate H et al. (2018) Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis. Thorax 73:134-144 |
| Rosen, Bradley H; Chanson, Marc; Gawenis, Lara R et al. (2018) Animal and model systems for studying cystic fibrosis. J Cyst Fibros 17:S28-S34 |
| Diehl, Lauri; Meyerholz, David K; Day, Michael J et al. (2018) Pathology and Pathogenesis of Immune-Mediated Diseases of Animals. Vet Pathol 55:5-7 |
| Caswell, Jeff L; Bassel, Laura L; Rothenburger, Jamie L et al. (2018) Observational Study Design in Veterinary Pathology, Part 2: Methodology. Vet Pathol 55:774-785 |
| Trillo-Muyo, Sergio; Nilsson, Harriet E; Recktenwald, Christian V et al. (2018) Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers. J Biol Chem 293:5746-5754 |
| Yoshida, Mitsuteru; Oishi, Hisashi; Martinu, Tereza et al. (2018) Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model. Oncotarget 9:8489-8501 |
| Thornell, Ian M; Li, Xiaopeng; Tang, Xiao Xiao et al. (2018) Nominal carbonic anhydrase activity minimizes airway-surface liquid pH changes during breathing. Physiol Rep 6: |
| Clippinger, Amy J; Allen, David; Behrsing, Holger et al. (2018) Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity. Toxicol In Vitro 52:131-145 |
| Cheng, Sunny Lihua; Li, Xueshu; Lehmler, Hans-Joachim et al. (2018) Gut Microbiota Modulates Interactions Between Polychlorinated Biphenyls and Bile Acid Homeostasis. Toxicol Sci 166:269-287 |
| Cooney, Ashley L; McCray Jr, Paul B; Sinn, Patrick L (2018) Cystic Fibrosis Gene Therapy: Looking Back, Looking Forward. Genes (Basel) 9: |
Showing the most recent 10 out of 669 publications
