Abstract

(Comparative Pathology Core?Core 4) The goal of the Comparative Pathology Core is to provide professional services and expertise to Center Investigators of the Cystic Fibrosis Research and Translation Core Center. To facilitate these goals the Pathology Core offers 1) technical expertise and support for histotechnology techniques from tissue processing to specialized staining (histochemical and immunohistochemical) and 2) ACVP-boarded veterinary pathologist expertise and support for morphologic, quantitative and semi-quantitative evaluation of tissues from CF pig, CF mouse and CF ferret studies. The Comparative Pathology Core will provide services to Center Investigators in a timely and efficient manner for optimal assessment of tissues. The goals of the Comparative Pathology Core are to: 1. Provide histotechnology services to the Center Investigators through CPL resources and experienced staff. 2. Assist with professional necropsy services for Center Investigators. 3. Provide veterinary pathologists services to the Center Investigators. 4. Serve as a conduit for dissemination of histologic specimens from CF pig and ferret models to researchers outside the University of Iowa.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK054759-21
Application #
9983933
Study Section
Special Emphasis Panel (ZDK1)
Project Start
1998-09-30
Project End
2025-03-31
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
21
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Kroken, Abby R; Chen, Camille K; Evans, David J et al. (2018) The Impact of ExoS on Pseudomonas aeruginosa Internalization by Epithelial Cells Is Independent of fleQ and Correlates with Bistability of Type Three Secretion System Gene Expression. MBio 9:
Janssen, Kayley H; Diaz, Manisha R; Gode, Cindy J et al. (2018) RsmV, a Small Noncoding Regulatory RNA in Pseudomonas aeruginosa That Sequesters RsmA and RsmF from Target mRNAs. J Bacteriol 200:
Li, Xingnan; Ortega, Victor E; Ampleford, Elizabeth J et al. (2018) Genome-wide association study of lung function and clinical implication in heavy smokers. BMC Med Genet 19:134
Putcha, Nirupama; Paul, Gabriel G; Azar, Antoine et al. (2018) Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS. PLoS One 13:e0194924
Haghighi, Babak; D Ellingwood, Nathan; Yin, Youbing et al. (2018) A GPU-based symmetric non-rigid image registration method in human lung. Med Biol Eng Comput 56:355-371
Janssen, Kayley H; Diaz, Manisha R; Golden, Matthew et al. (2018) Functional Analyses of the RsmY and RsmZ Small Noncoding Regulatory RNAs in Pseudomonas aeruginosa. J Bacteriol 200:
Sebag, Sara C; Koval, Olha M; Paschke, John D et al. (2018) Inhibition of the mitochondrial calcium uniporter prevents IL-13 and allergen-mediated airway epithelial apoptosis and loss of barrier function. Exp Cell Res 362:400-411
Rosen, Bradley H; Evans, T Idil Apak; Moll, Shashanna R et al. (2018) Infection Is Not Required for Mucoinflammatory Lung Disease in CFTR-Knockout Ferrets. Am J Respir Crit Care Med 197:1308-1318
Guo, Ang; Chen, Rong; Wang, Yihui et al. (2018) Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca2+]i in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity. J Mol Cell Cardiol 115:104-114
Smith, Benjamin M; Traboulsi, Hussein; Austin, John H M et al. (2018) Human airway branch variation and chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A 115:E974-E981

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