(Pilot Program) The main goal of the proposed Center's Pilot Program is to foster the career development of junior investigators carrying out research in the field of cystic fibrosis (CF). A secondary goal is to attract more senior investigators from outside the field into areas of CF research. One mechanism that has been key to achieving these goals is our Pilot Program, which provides seed money for research that has not yet reached the stage of maturity necessary to garner funding through traditional NIH mechanisms. During the 21 years that the P30 Pilot Program has been running, it has funded 66 pilots in areas of CF research and other genetic diseases. Numerous junior investigators funded through this program have gone onto develop independent and well funded research programs. Prior to 2014, P30 Pilots included other genetic diseases and after that they were required to be focused on CF (including lung). In keeping with the overall shift of the Center's focus for this funding cycle, revisions to the Pilot Program include a requirement for the research to be focused on CF research related to the NIDDK mission (i.e., excluding lung). The Pilot Program is run through the Center's Administrative Core, with oversight from three committees: the Pilot and Feasibility Committee, the Executive Committee, and the External Advisory Committee. These groups take into account two external reviews per application in making decisions about funding. Progress of the pilot projects is monitored through numerous forums that are supported by the Center's Enrichment Program, and awardees are provided with extensive, constructive feedback that greatly facilitates the evolution of their research. In this section, we will summarize the progress made in past pilot projects and the success that many of the pilot holders have had to date. Notably, the 7 pilot grants that were funded during the last 5-year funding period resulted in 25 publications.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1)
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University of Iowa
Iowa City
United States
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Bhatt, Surya P; Washko, George R; Hoffman, Eric A et al. (2018) Imaging Advances in Chronic Obstructive Pulmonary Disease: Insights from COPDGene. Am J Respir Crit Care Med :
Sweeney, Sean K; Manzar, Gohar S; Zavazava, Nicholas et al. (2018) Tracking embryonic hematopoietic stem cells to the bone marrow: nanoparticle options to evaluate transplantation efficiency. Stem Cell Res Ther 9:204
Kim, Jeeyeon; Farahmand, Miesha; Dunn, Colleen et al. (2018) Sweat rate analysis of ivacaftor potentiation of CFTR in non-CF adults. Sci Rep 8:16233
Cooney, Ashley L; Singh, Brajesh K; Loza, Laura Marquez et al. (2018) Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus. Nucleic Acids Res 46:9591-9600
Bhatt, Surya P; Bhakta, Nirav R; Wilson, Carla G et al. (2018) New Spirometry Indices for Detecting Mild Airflow Obstruction. Sci Rep 8:17484
Meyerholz, David K; Beck, Amanda P; Goeken, J Adam et al. (2018) Glycogen depletion can increase the specificity of mucin detection in airway tissues. BMC Res Notes 11:763
Polgreen, Philip M; Brown, Grant D; Hornick, Douglas B et al. (2018) CFTR Heterozygotes Are at Increased Risk of Respiratory Infections: A Population-Based Study. Open Forum Infect Dis 5:ofy219
Wang, Zekun; Cheng, Fang; Engelhardt, John F et al. (2018) Development of a Novel Recombinant Adeno-Associated Virus Production System Using Human Bocavirus 1 Helper Genes. Mol Ther Methods Clin Dev 11:40-51
Allen, Rondine J; Mathew, Basil; Rice, Kevin G (2018) PEG-Peptide Inhibition of Scavenger Receptor Uptake of Nanoparticles by the Liver. Mol Pharm 15:3881-3891
Martinez, Fernando J; Han, MeiLan K; Allinson, James P et al. (2018) At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 197:1540-1551

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