This application is submitted in response to RFA DK-04-014, Silvio O. Conte Digestive Diseases Research Core Center, requesting continued funding of the Texas Gulf Coast Digestive Diseases Center (called DDC for simplicity). This Center serves basic and clinical scientists at institutions within the Texas Medical Center (Baylor College of Medicine, The University of Texas Health Science Center at Houston) and at the University of Texas Medical Branch in Galveston. Our qualifying Funded Research Base is $22,182,225 million (direct costs) and includes 44 separate awards from NIDDK totaling $9,016,286 million (direct costs). Reflecting the goals of these projects, this is a Center for Gastrointestinal Development, Infection and Injury. This Center was developed from a core group of investigators who began interacting formally in 1996, to explore the need and interest in establishing a DDC. These interactions were initiated by a Pediatric Training Program in Gastroenterology at Baylor whose faculty represent key investigators in our DDC. Institutional resource commitments in space, funds and personnel support this effort, including new positions in basic and clinical departments for multidiscliplinary, independent, faculty to establish new research programs. This Center facilitates on-going Digestive Diseases research, promotes translational research between basic and clinical areas, develops new projects, nurtures new investigators, and provides GI educational activities. Support is requested for an Administrative Core, four Basic Science Cores (Morphology, Gene Expression and Proteomics, Gastrointestinal Immunology, Integrative Biology) and one Clinical Core (Study Design and Clinical Research Support). Pilot/Feasibility and Enrichment Programs, including a Career Development Initiative, to support innovative ideas and new investigators in Digestive Disease research and foster collaboration are a key part of the DDC, and have been extremely successful The Center draws together a multidisciplinary group of investigators, including basic scientists with proven track records of success, and well-coordinated clinical programs dealing with pediatric and adult GI patients. Center leaders are senior scientists-administrators experienced in directing interactive, multidisciplinary programs. A large, multi-ethnic population of infants and adults with Digestive Diseases emphasizes the need and the opportunities for this Center. Various groups involved in GI research and education in the Gulf Coast Area of Texas have shown the willingness to enthusiastically work with the Center. This NIDDK-funded DDRCC will promote and coordinate Digestive Disease activities in the area.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK056338-10
Application #
8230735
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (O1))
Program Officer
Podskalny, Judith M,
Project Start
1999-12-01
Project End
2013-02-28
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
10
Fiscal Year
2012
Total Cost
$1,148,666
Indirect Cost
$361,451
Name
Baylor College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Alvarado, Gabriela; Ettayebi, Khalil; Atmar, Robert L et al. (2018) Human Monoclonal Antibodies That Neutralize Pandemic GII.4 Noroviruses. Gastroenterology 155:1898-1907
Wang, Zhensheng; Graham, David Y; Khan, Anam et al. (2018) Incidence of gastric cancer in the USA during 1999 to 2013: a 50-state analysis. Int J Epidemiol :
Petrosino, Joseph F (2018) The microbiome in precision medicine: the way forward. Genome Med 10:12
Kanwal, Fasiha; Kramer, Jennifer R; Mapakshi, Srikar et al. (2018) Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty Liver Disease. Gastroenterology 155:1828-1837.e2
Costantini, Veronica; Morantz, Esther K; Browne, Hannah et al. (2018) Human Norovirus Replication in Human Intestinal Enteroids as Model to Evaluate Virus Inactivation. Emerg Infect Dis 24:1453-1464
Cruz, Ligia Alfaro; Kaul, Isha; Zhang, Yan et al. (2018) Assessment of Quality and Readability of Internet Dietary Information on Irritable Bowel Syndrome. Clin Gastroenterol Hepatol :
Kramer, J R; Puenpatom, A; Erickson, K F et al. (2018) Real-world effectiveness of elbasvir/grazoprevir In HCV-infected patients in the US veterans affairs healthcare system. J Viral Hepat 25:1270-1279
Stewart, Christopher J; Auchtung, Thomas A; Ajami, Nadim J et al. (2018) Effects of tobacco smoke and electronic cigarette vapor exposure on the oral and gut microbiota in humans: a pilot study. PeerJ 6:e4693
Hernaez, Ruben; Kanwal, Fasiha; El-Serag, Hashem B (2018) Hepatocellular carcinoma screening is associated with survival benefit in silico but needs confirmation in an in vivo analysis. Hepatology 68:7-9
Chiang, Yun-Chen; Park, In-Young; Terzo, Esteban A et al. (2018) SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma. Cancer Res 78:3135-3146

Showing the most recent 10 out of 1121 publications