The primary goal of the recently renamed Functional Genomics and Microbiome Core (Core C) is to enhance research programs in infection and injury states affecting the mammalian intestine and liver by providing genomics and metagenomics expertise and resources. In this Core, we utilize advanced technology in mammalian and microbial genomics to support ongoing and innovative research to prevent and cure digestive diseases. This Core enables investigators to posit research questions related to gene expression, functional genomics and molecular mechanisms by utilizing the tools of microarrays, deep nucleic acid sequencing (microbial and mammalian), nucleic acid amplification, protein profiling, and bioinformatics. PCR based analyses of gene expression and splicing, DNA mutation/SNP detection, and gene pathway analyses ofthe mammalian metagenome (microbe and man) will be fostered by this Core as a platform for gastrointestinal and hepatic systems biology. Our mission is to provide a full service resource from experimental design to consultations about specimen processing, robust data analysis pipelines, and biostatistical support. In summary, we have created a fully integrated genomic analysis platform for investigators studying digestive diseases.

Public Health Relevance

This Core provides help with complex molecular technologies such as gene expression profiling and genomic microarray analyses, complex protein bead assays, metagenomic sequencing and microbiome analyses needed by DDC members.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK056338-12
Application #
8611914
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
12
Fiscal Year
2014
Total Cost
$195,625
Indirect Cost
$70,625
Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Hoang, Thomas K; He, Baokun; Wang, Ting et al. (2018) Protective effect of Lactobacillus reuteri DSM 17938 against experimental necrotizing enterocolitis is mediated by Toll-like receptor 2. Am J Physiol Gastrointest Liver Physiol 315:G231-G240
Weatherhead, Jill E; Porter, Paul; Coffey, Amy et al. (2018) Ascaris Larval Infection and Lung Invasion Directly Induce Severe Allergic Airway Disease in Mice. Infect Immun 86:
Gracz, Adam D; Samsa, Leigh Ann; Fordham, Matthew J et al. (2018) Sox4 Promotes Atoh1-Independent Intestinal Secretory Differentiation Toward Tuft and Enteroendocrine Fates. Gastroenterology 155:1508-1523.e10
Martinez-Guryn, Kristina; Hubert, Nathaniel; Frazier, Katya et al. (2018) Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids. Cell Host Microbe 23:458-469.e5
Hammad, Tariq A; Thrift, Aaron P; El-Serag, Hashem B et al. (2018) Missed Opportunities for Screening and Surveillance of Barrett's Esophagus in Veterans with Esophageal Adenocarcinoma. Dig Dis Sci :
Kotlajich, Matthew V; Xia, Jun; Zhai, Yin et al. (2018) Fluorescent fusions of the N protein of phage Mu label DNA damage in living cells. DNA Repair (Amst) 72:86-92
Mindikoglu, Ayse L; Opekun, Antone R; Putluri, Nagireddy et al. (2018) Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis. Transl Res 195:25-47
Jiang, Zhi-Dong; Jenq, Robert R; Ajami, Nadim J et al. (2018) Safety and preliminary efficacy of orally administered lyophilized fecal microbiota product compared with frozen product given by enema for recurrent Clostridium difficile infection: A randomized clinical trial. PLoS One 13:e0205064
Chumpitazi, Bruno P; Lim, Jongbin; McMeans, Ann R et al. (2018) Evaluation of FODMAP Carbohydrates Content in Selected Foods in the United States. J Pediatr 199:252-255
Tayob, Nabihah; Richardson, Peter; White, Donna L et al. (2018) Evaluating screening approaches for hepatocellular carcinoma in a cohort of HCV related cirrhosis patients from the Veteran's Affairs Health Care System. BMC Med Res Methodol 18:1

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