Abstract

The goal of the BMAC is to offer a comprehensive range of MS analyses for the structural characterization and quantification of nutrition-related biomolecules for NORC investigators. The predominant BMAC objective is to provide means for NORC investigators to gain maximum benefit from the power of MS with a focus on three areas of need: 1) To apply the sensitivity and specificity of MS to detect and quantify low abundance biomolecules;2) To develop innovative MS techniques for detection and structural characterization of nutritionor obesity-related biomolecules;and 3) To provide MS training for students and fellows in nutrition or obesity research. Because MS analyses are labor-intensive and require specialized skills, it is often more economical and practical for BMAC Core staff to perform MS analyses. In cases where sustained demand for analyses or development of analytical techniques is anticipated, members of investigators'laboratories are trained to perform appropriate MS procedures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK056341-11
Application #
8132692
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (J2))
Project Start
2011-04-01
Project End
2016-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
11
Fiscal Year
2011
Total Cost
$89,254
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Acevedo, María Belén; Ferrando, Ramiro; Patterson, Bruce W et al. (2018) Effect of alcohol ingestion on plasma glucose kinetics after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis :
Sun, Shishuo; Tan, Pengcheng; Huang, Xiaoheng et al. (2018) Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes. J Biol Chem 293:2383-2394
van Vliet, Stephan; Smith, Gordon I; Porter, Lane et al. (2018) The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone. J Physiol 596:4681-4692
Frolova, Antonina I; Wang, Judy J; Conner, Shayna N et al. (2018) Spontaneous Labor Onset and Outcomes in Obese Women at Term. Am J Perinatol 35:59-64
Shibao, Cyndya A; Celedonio, Jorge E; Tamboli, Robyn et al. (2018) CD36 Modulates Fasting and Preabsorptive Hormone and Bile Acid Levels. J Clin Endocrinol Metab 103:1856-1866
Turk, John; White, Tayleur D; Nelson, Alexander J et al. (2018) iPLA2? and its role in male fertility, neurological disorders, metabolic disorders, and inflammation. Biochim Biophys Acta Mol Cell Biol Lipids :
Goldner, Nicholas K; Bulow, Christopher; Cho, Kevin et al. (2018) Mechanism of High-Level Daptomycin Resistance in Corynebacterium striatum. mSphere 3:
Mukherjee, Sumit; Xu, Wei; Hsu, Fong-Fu et al. (2018) Sterol methyltransferase is required for optimal mitochondrial function and virulence in Leishmania major. Mol Microbiol :
Wildburger, Norelle C; Gyngard, Frank; Guillermier, Christelle et al. (2018) Amyloid-? Plaques in Clinical Alzheimer's Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity. Front Neurol 9:169
Higgins, Cassandra B; Zhang, Yiming; Mayer, Allyson L et al. (2018) Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPAR?. JCI Insight 3:

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