The Animal Model Research Core facility of the NORC is to facilitate the research efforts of investigators pursuing scientific problems relevant to obesity and nutrition that involve murine models. The Core, since its inception more than a decade ago, has focused on providing services that will enhance the translational potential of animal research to increase the likelihood that research activities will lead to clinically meaningful results. Core services include: providing genetically engineered mice;performing biochemical assays of serum and tissue from mouse models;imunocytochemistry;performing in vivo metabolic testing (including metabolc rate, blood pressure, glucose tolerance and insulin tolerance testing, hyperinsulinemic/euglycemic clamp procedures, and body composition determinations);providing facilities for mRNA assays and atherosclerosis assays;and providing training and consultation for animal maintenance and phenotyping. During this last funding period, the Core assisted young investigators as they established their careers in nutrition and obesity research, attracted senior investigators from other scientific disciplines to nutrition research, and supported nutritional researchers as they made important observations with clear translational potential. This was accomplished by performing nearly 39,000 biochemical assays of mouse serum, over 3,200 biochemical assays of tissues, characterizing 278 mice by indirect calorimetry, measuring blood pressure in 738 mice, performing 3,812 body composition determinations in mice, and providing over 100 clock hours of training in nutrition-related techniques, among other activities. The Core has benefited from synergies achieved through joint operation with the Mouse Phenotyping Core ofthe NlDDK-funded Washington University Diabetes Research and Training Center (DRTC) and substantial institutional investments. In the next funding period, the Core plans to maintain our tradition of excellence through continued service, training and support, and to enhance our capabilities by offering in vivo animal imaging to NORC investigators performing research in obesity and nutrition.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Saint Louis
United States
Zip Code
Shepherd, Andrew J; Copits, Bryan A; Mickle, Aaron D et al. (2018) Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain. J Neurosci 38:7032-7057
Cifarelli, Vincenza; Abumrad, Nada A (2018) Intestinal CD36 and Other Key Proteins of Lipid Utilization: Role in Absorption and Gut Homeostasis. Compr Physiol 8:493-507
Perry, Justin S A; Russler-Germain, Emilie V; Zhou, You W et al. (2018) Transfer of Cell-Surface Antigens by Scavenger Receptor CD36 Promotes Thymic Regulatory T Cell Receptor Repertoire Development and Allo-tolerance. Immunity 48:1271
Smith, Gordon I; Commean, Paul K; Reeds, Dominic N et al. (2018) Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength: A Randomized Controlled Study. Obesity (Silver Spring) 26:854-861
Samovski, Dmitri; Dhule, Pallavi; Pietka, Terri et al. (2018) Regulation of Insulin Receptor Pathway and Glucose Metabolism by CD36 Signaling. Diabetes 67:1272-1284
Turecamo, S E; Walji, T A; Broekelmann, T J et al. (2018) Contribution of metabolic disease to bone fragility in MAGP1-deficient mice. Matrix Biol 67:1-14
Acevedo, María Belén; Eagon, J Christopher; Bartholow, Bruce D et al. (2018) Sleeve gastrectomy surgery: when 2 alcoholic drinks are converted to 4. Surg Obes Relat Dis 14:277-283
Porter, Lane C; Franczyk, Michael P; Pietka, Terri et al. (2018) NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism. Am J Physiol Endocrinol Metab 315:E520-E530
Henson, William R; Hsu, Fong-Fu; Dantas, Gautam et al. (2018) Lipid metabolism of phenol-tolerant Rhodococcus opacus strains for lignin bioconversion. Biotechnol Biofuels 11:339
Mikhalkova, Deana; Holman, Sujata R; Jiang, Hui et al. (2018) Bariatric Surgery-Induced Cardiac and Lipidomic Changes in Obesity-Related Heart Failure with Preserved Ejection Fraction. Obesity (Silver Spring) 26:284-290

Showing the most recent 10 out of 1334 publications