application): The purpose of the Molecular Biology and Biochemistry Core is to provide a state-of-the-art facility for nutrition research investigators. For molecular biology work, the Core will provide a number of specialized techniques that were identified as the most popular assays by CNRU investigators. In addition, the Core will consult with and assist investigators who may be just beginning to use molecular techniques in their research. Thus, the Core will assist both novices and more experienced users in developing and implementing modern molecular biology techniques. The Core seeks to make molecular biology techniques accessible to all levels of users. Both training and education are emphasized functions of the Core. The Core will advise and train investigators or their research personnel to plan and carry out new techniques in their own laboratories. The Core will also advise investigators who are experiencing technical difficulties, and will provide limited storage space for samples before testing. For biochemical research, the Core will perform standard assays for a number of biochemical measurements. The particular assays were chosen in consultation with CNRU investigators and reflect both current and pending research projects. The Core will provide standardized testing for investigators who may have neither the time nor the expertise to establish each of these assays in their own laboratories. In addition to advising and training CNRU investigators in new methods and assays, the Core (in coordination with Core B- Nutrition-Epidemiology) will assist in selecting and developing novel biomarkers. Again, as for the molecular biology component, the biochemistry component will educate investigators in how biomarkers can enhance their research. The basic purpose of this Core is to encourage and facilitate application of molecular biology tools in nutritional research and to provide assays for biomarkers that can enhance epidemiological nutritional studies. The specific objectives of the Core are: 1.Serve as an educational and training resource for developing and applying molecular biology techniques and biomarkers for nutritional research; 2. Provide service to investigators that include methods to detect and measure mRNA and genetic polymorphisms, to assay various enzymes, and to measure markers of oxidative stress; 3.Provide storage for samples before testing; 4. Provide specialized facilities and equipment for molecular biology and biochemistry assays; 5. Facilitate collaborations between CNRU investigators.

Project Start
2002-09-30
Project End
2003-09-29
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Pietryk, Edward W; Clement, Kiristin; Elnagheeb, Marwa et al. (2018) Intergenerational response to the endocrine disruptor vinclozolin is influenced by maternal genotype and crossing scheme. Reprod Toxicol 78:9-19
Warren, Joshua L; Gordon-Larsen, Penny (2018) Factors associated with supermarket and convenience store closure: a discrete time spatial survival modelling approach. J R Stat Soc Ser A Stat Soc 181:783-802
Felix, Janine F; Joubert, Bonnie R; Baccarelli, Andrea A et al. (2018) Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. Int J Epidemiol 47:22-23u
Ren, Huihui; Liu, Zhelong; Zhou, Xinrong et al. (2018) Association of sleep duration with apolipoproteins and the apolipoprotein B/A1 ratio: the China health and nutrition survey. Nutr Metab (Lond) 15:1
Xu, Hongwei (2018) Multilevel socioeconomic differentials in allostatic load among Chinese adults. Health Place 53:182-192
Kay, Melissa C; Wasser, Heather; Adair, Linda S et al. (2018) Consumption of obesogenic foods in non-Hispanic black mother-infant dyads. Matern Child Nutr 14:
Wang, Z; Siega-Riz, A M; Gordon-Larsen, P et al. (2018) Diet quality and its association with type 2 diabetes and major cardiometabolic risk factors among adults in China. Nutr Metab Cardiovasc Dis 28:987-1001
Sauder, K A; Dabelea, D; Bailey-Callahan, R et al. (2018) Targeting risk factors for type 2 diabetes in American Indian youth: the Tribal Turning Point pilot study. Pediatr Obes 13:321-329
Barkin, Shari L; Heerman, William J; Sommer, Evan C et al. (2018) Effect of a Behavioral Intervention for Underserved Preschool-Age Children on Change in Body Mass Index: A Randomized Clinical Trial. JAMA 320:450-460
Stieglitz, Heather M; Korpi-Steiner, Nichole; Katzman, Brooke et al. (2018) Suspected Testosterone-Producing Tumor in a Patient Taking Biotin Supplements. J Endocr Soc 2:563-569

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