I. Evolution of the NORC Research Base. The strength of the UNC NORC research base is that it is both large enough and strong enough to effectively span a variety of disciplines within nutritional sciences and obesity related research. From population-based to molecular research, our Center gains from the integration of these diverse perspectives and approaches. Our faculty members are international leaders in nutrition and obesity research, publishing in top journals and directing major nutrition/obesity studies. At the population level, our investigators lead some of the largest NIH-funded nutrition-focused studies including the Long Island Breast Cancer Study (18,000 women), Atherosclerosis Risk in Communities (ARIC: 15,792 men and women), Trial of Activity in Adolescent Girls (TAAG: 8,728 women), WAY to Health Study (1,200 employees at 12 community colleges), The Hispanic Cohort Health Study (16,000 men and women) and the Carolina Head and Neck Cancer Study (CHANCE: 1,400 men and women), to name a few. Our investigators are at the leading edge of studying the global nutrition transition, with major longitudinal studies in the United States, China and the Philippines. At the clinical nutrition research level, we are leaders in the developing field of nutrigenomics as it influences dietary nutrient requirements (including organizing workshops for the American Society of Nutrition at the 2010 and 2011 Experimental Biology annual meetings). Our members have generated critical information needed for the Dietary Reference Intakes (DRI) development process, and several of our members served on the Institute of Medicine panels that developed those DRIs. At the molecular level, our investigators have made fundamental contributions to the understanding of the genes that regulate activity, lipid and choline metabolism, the effects of obesity on immune responses to viruses, and the mechanisms whereby antioxidants and selenium modulate viral mutation and pathogenesis. We are also leaders in identifying, in both mice and humans, gene loci that regulate adipose distribution, insulin resistance, and glucose metabolism. These examples are only a small portion of the large number of contributions made by the NORC research base. The NORC leadership has worked hard to build a strong and diverse research base. We measure our success as a Center by the strength of our membership, the investment in nutrition and obesity research, and the quantity and quality of publications generated by our members.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK056350-14
Application #
8640924
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Evans, Mary
Project Start
1999-09-30
Project End
2016-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
14
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Nutrition
Type
Schools of Public Health
DUNS #
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Pace, Nelson D; Desrosiers, Tania A; Carmichael, Suzan L et al. (2018) Antioxidant Consumption is Associated with Decreased Odds of Congenital Limb Deficiencies. Paediatr Perinat Epidemiol 32:90-99
Jia, Xiaofang; Liu, Jiawu; Chen, Bo et al. (2018) Differences in nutrient and energy contents of commonly consumed dishes prepared in restaurants v. at home in Hunan Province, China. Public Health Nutr 21:1307-1318
Noar, Seth M; Kelley, Dannielle E; Boynton, Marcella H et al. (2018) Identifying principles for effective messages about chemicals in cigarette smoke. Prev Med 106:31-37
Widman, Laura; Golin, Carol E; Kamke, Kristyn et al. (2018) Sexual Assertiveness Skills and Sexual Decision-Making in Adolescent Girls: Randomized Controlled Trial of an Online Program. Am J Public Health 108:96-102
Blue, R Eric; Curry, Ennessa G; Engels, Nichlas M et al. (2018) How alternative splicing affects membrane-trafficking dynamics. J Cell Sci 131:
Smith-Ryan, Abbie E; Blue, Malia N M; Trexler, Eric T et al. (2018) Utility of ultrasound for body fat assessment: validity and reliability compared to a multicompartment criterion. Clin Physiol Funct Imaging 38:220-226
Buglak, Nicholas E; Batrakova, Elena V; Mota, Roberto et al. (2018) Insights on Localized and Systemic Delivery of Redox-Based Therapeutics. Oxid Med Cell Longev 2018:2468457
Birken, Sarah A; Rohweder, Catherine L; Powell, Byron J et al. (2018) T-CaST: an implementation theory comparison and selection tool. Implement Sci 13:143
Branca, Rosa T; McCallister, Andrew; Yuan, Hong et al. (2018) Accurate quantification of brown adipose tissue mass by xenon-enhanced computed tomography. Proc Natl Acad Sci U S A 115:174-179
Dover, E Nicole; Patel, Naishal Y; St├Żblo, Miroslav (2018) Impact of in vitro heavy metal exposure on pancreatic ?-cell function. Toxicol Lett 299:137-144

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