Pancreatic islet transplantation has made great advances in the last decade marked by improved durability of islet function post transplant. These efforts are in part attributable to development of a standardized manufacturing process that has increased yield and consistency of the isolation. Recent advances can in part be attributed to the Clinical Islet Transplant (CIT) consortium effort through which an expert team of islet scientists and clinicians designed an islet manufacturing protocol for the phase III trials currently underway. Dissemination of this technology has made the production of high quality islets common at multiple US sites. Isolated human pancreatic islets are requisite not only for clinical transplant trials but also have become an invaluable material resource for investigators studying islet biology, physiology, beta cell proliferation, autoimmunity and Type II diabetes. The primary object of the proposed core is to provide high quality islets using the CIT manufacturing protocol to investigators working in the BADERC. The core will take advantage of: 1) an expert and well established islet isolation team with a proven track record of preparing islets for clinical and research purposes, 2) an existing MGH GMP isolation laboratory and islet core infrastructure, and 3) an abundance of available pancreata in New England as there currently is no competition for such organs. Based on these assets, we will be able to make available high quality human islets for research investigations to members of the BADERC tailored to their specific needs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK057521-18
Application #
9267973
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
18
Fiscal Year
2017
Total Cost
$93,960
Indirect Cost
$39,960
Name
Massachusetts General Hospital
Department
Type
Independent Hospitals
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114
Fulzele, Keertik; Dedic, Christopher; Lai, Forest et al. (2018) Loss of Gs? in osteocytes leads to osteopenia due to sclerostin induced suppression of osteoblast activity. Bone 117:138-148
Battistone, Maria A; Nair, Anil V; Barton, Claire R et al. (2018) Extracellular Adenosine Stimulates Vacuolar ATPase-Dependent Proton Secretion in Medullary Intercalated Cells. J Am Soc Nephrol 29:545-556
Cheung, Pui W; Terlouw, Abby; Janssen, Sam Antoon et al. (2018) Inhibition of non-receptor tyrosine kinase Src induces phosphoserine 256-independent aquaporin-2 membrane accumulation. J Physiol :
Karim, Lamya; Moulton, Julia; Van Vliet, Miranda et al. (2018) Bone microarchitecture, biomechanical properties, and advanced glycation end-products in the proximal femur of adults with type 2 diabetes. Bone 114:32-39
Kolar, Matthew J; Nelson, Andrew T; Chang, Tina et al. (2018) Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements. Anal Chem 90:5358-5365
Todd, William D; Fenselau, Henning; Wang, Joshua L et al. (2018) A hypothalamic circuit for the circadian control of aggression. Nat Neurosci 21:717-724
Cox, Kimberly H; Oliveira, Luciana M B; Plummer, Lacey et al. (2018) Modeling mutant/wild-type interactions to ascertain pathogenicity of PROKR2 missense variants in patients with isolated GnRH deficiency. Hum Mol Genet 27:338-350
Aguayo-Mazzucato, Cristina; Bonner-Weir, Susan (2018) Pancreatic ? Cell Regeneration as a Possible Therapy for Diabetes. Cell Metab 27:57-67
McKeown, Nicola M; Dashti, Hassan S; Ma, Jiantao et al. (2018) Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis. Diabetologia 61:317-330
Vandoorne, Katrien; Rohde, David; Kim, Hye-Yeong et al. (2018) Imaging the Vascular Bone Marrow Niche During Inflammatory Stress. Circ Res 123:415-427

Showing the most recent 10 out of 389 publications