The GI Surgical Modeling Core provides unique murine surgical services (bariatric and other novel surgical procedures). This core was established to enhance the investigative efforts of the VDDRC investigators and provide avenues of research that otherwise would not be feasible. The primary rational for the core rests in the growing number of mice having genetic alterations with relevance or potential relevance to digestive diseases and the need for surgical and experimental techniques that are necessary to study the impact of genetic (or pharmacologic) manipulations. The procedures require skill and practice in order to study healthy, unstressed mice. The core has skilled surgeons that are capable of adapting a range of procedures to suit specific needs of VDDRC members including bariatric surgical procedures, surgical models for Barrett's esophagus and liver transplantation and ischemia/reperfusion injury models. The quality of the results that are obtained using surgical models is directly related to the general health of the animal. The Core has placed significant emphasis on providing murine models that are free of avoidable, undesired complications. Pre and post-operative care is as important to the success of the procedure as the surgical procedure itself. The overall goal of the core is to provide murine models of bariatric surgery using procedures that are designed to reflect those performed in humans, liver transplantation, and unique customized surgical models adapted to the needs of VDDRC members. To achieve this goal the core: 1. Provides mouse bariatric surgery models with application to basic and translational research. 2. Provides mouse models of Barrett's esophagus and liver and small bowel transplantation. 3. Provides peri-operative care to ensure that animals are healthy and free of undue stress. 4. Trains investigators in specialized surgical procedures. 5. Responds to the needs of VDDRC investigators through development of new procedures. The Core interacts closely with other VDDRC Cores, the Mouse Metabolic Phenotyping Center (MMPC), the Diabetes Research and Training Center, and the Division of Animal Care to ensure and maximize efficient use of resources and personnel and enhance interdisciplinary collaboration.

Public Health Relevance

This core is relevant to the mission of the VDDRC as it will provide novel mouse surgical models that replicate procedures that affect gastrointestinal function in humans. These surgical models, when coupled with genetically altered mice, will be a powerful resource for establishing mechanisms of gastrointestinal function.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
United States
Zip Code
Hebron, Katie E; Li, Elizabeth Y; Arnold Egloff, Shanna A et al. (2018) Alternative splicing of ALCAM enables tunable regulation of cell-cell adhesion through differential proteolysis. Sci Rep 8:3208
Pollins, Alonda C; Boyer, Richard B; Nussenbaum, Marlieke et al. (2018) Comparing Processed Nerve Allografts and Assessing Their Capacity to Retain and Release Nerve Growth Factor. Ann Plast Surg 81:198-202
Ruiz, Rachel M; Sommer, Evan C; Tracy, Dustin et al. (2018) Novel patterns of physical activity in a large sample of preschool-aged children. BMC Public Health 18:242
Scoville, Elizabeth A; Allaman, Margaret M; Brown, Caroline T et al. (2018) Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics 14:
Loh, John T; Beckett, Amber C; Scholz, Matthew B et al. (2018) High-Salt Conditions Alter Transcription of Helicobacter pylori Genes Encoding Outer Membrane Proteins. Infect Immun 86:
Bolus, W Reid; Peterson, Kristin R; Hubler, Merla J et al. (2018) Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments. Mol Metab 8:86-95
Kroh, Heather K; Chandrasekaran, Ramyavardhanee; Zhang, Zhifen et al. (2018) A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells. J Biol Chem 293:941-952
Noto, Jennifer M; Chopra, Abha; Loh, John T et al. (2018) Pan-genomic analyses identify key Helicobacter pylori pathogenic loci modified by carcinogenic host microenvironments. Gut 67:1793-1804
Kohl, Kevin D; Dearing, M Denise; Bordenstein, Seth R (2018) Microbial communities exhibit host species distinguishability and phylosymbiosis along the length of the gastrointestinal tract. Mol Ecol 27:1874-1883
Kook, Seunghyi; Qi, Aidong; Wang, Ping et al. (2018) Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes. Am J Respir Cell Mol Biol 58:566-574

Showing the most recent 10 out of 1365 publications