The overall mission ofthe UCSD/UCLA DRC confinues to center on fostering research in the prevention and treatment of diabetes and its complicafions to ultimately improve the lives of patierits. For the past decade, our DRC has been unique in linking together the diabetes/metabolism activifies of two major universities within the UC system. We believe this has been a novel, and a very successful effort;Thus, we have been able harness the collective energy and scientific excitement at UCSD/Salk and UCLA/Cedars-Sinai, which comprise the major proportion of research in diabetes/metabolism in Southern California. The DRC has fostered new collaborations and interactions between outstanding scienfists within and across these insfitutions and has played an important role in promofing the careers of young scienfists as they move on to the status of independent invesfigators. Our research base faculty membership now includes 109 outstanding scienfists who have been excepfionally successful as can be judged by the numerous publicafions in high impact journals and the generous peer review grant support that they have accrued ($155 million dollars). Some selective highlights over the past four years include: (1) Organizafion of the Pediatric Diabetes Research Center (PDRC) at UCSD along with the addifion of the La Jolla Allergy and Immunology Institute (LIAI) on the UCSD campus, which brings a number of outstanding new faculty into the DRC, all focused exclusively on type 1 diabetes research. (2) Establishment and occupancy of the Institute for Regenerative Medicine on the UCSD campus which has a focus on human stem cell research and beta cell generafion (3) Major recruitments and addifion of diabetes/metabolism-based scientists at both UCLA and UCSD. For example, this includes Richard Bergman and Marilyn Ader, and their respecfive groups, at Cedars-Sinai, Kumar Sharma at UCSD, and Matthias von Herrath at LIAI. (4) Outstanding success of our P&F awardees as they move fonward and upward in their scientific careers. An acknowledgement of this, UCSD and UCLA have agreed to provide $100,000/year in unrestricted funds to augment our P&F program. (5) Establishment and confinuafion of several program project grants and center among our collaborafing DRC faculty, headed by Drs. Chris Glass, Pam Mellon, Susan Taylor, Aldons Lusis, Joe Witztum, and Steve Young. All of our Research cores have been updated with new services and state-of-the-art technologies in the upcoming project period. In addifion, we have added a new Novel Target Discovery and Assay Development Core to reflect the many advances in this field as they relate to diabetes and metabolism research.

Public Health Relevance

of the UCSD/UCLA DRC is promotion and enhancement of research into the mechanisms, etiology, pathophysiology, treatment, and prevention of diabetes mellitus and its complications and related metabolic disorders through the outstanding scientific accomplishments ofthe faculty comprising our research base, our biomedical research cores, the P&F Program, and the Enrichment Program and Administrative Cores. Our firm conviction is that success will ultimately improve the lives of patients with diabetes.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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University of California San Diego
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Seyerle, A A; Sitlani, C M; Noordam, R et al. (2018) Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology. Pharmacogenomics J 18:215-226
Gao, Chuan; Tabb, Keri L; Dimitrov, Latchezar M et al. (2018) Exome Sequencing Identifies Genetic Variants Associated with Circulating Lipid Levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS). Sci Rep 8:5603
Svensson, Kristoffer; Dent, Jess R; Tahvilian, Shahriar et al. (2018) Defining the contribution of skeletal muscle pyruvate dehydrogenase alpha 1 (Pdha1) to exercise performance and insulin action. Am J Physiol Endocrinol Metab :
Yuan, Xiaomei; Dong, Yi; Tsurushita, Naoya et al. (2018) CD122 blockade restores immunological tolerance in autoimmune type 1 diabetes via multiple mechanisms. JCI Insight 3:
Gong, J; Nishimura, K K; Fernandez-Rhodes, L et al. (2018) Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. Int J Obes (Lond) 42:384-390
Jo Hodonsky, Chani; Schurmann, Claudia; Schick, Ursula M et al. (2018) Generalization and fine mapping of red blood cell trait genetic associations to multi-ethnic populations: The PAGE Study. Am J Hematol :
Wang, Bo; Rong, Xin; Palladino, Elisa N D et al. (2018) Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis. Cell Stem Cell 22:206-220.e4
Prohaska, Thomas A; Que, Xuchu; Diehl, Cody J et al. (2018) Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies. J Immunol 200:1702-1717
Bihlmeyer, Nathan A; Brody, Jennifer A; Smith, Albert Vernon et al. (2018) ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals. Circ Genom Precis Med 11:e001758
Hernandez-Carretero, A; Weber, N; La Frano, M R et al. (2018) Obesity-induced changes in lipid mediators persist after weight loss. Int J Obes (Lond) 42:728-736

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