The Administrative Core is responsible for allocation, management, and oversight of DRC resources. The Administrative Core, in coordination with the DRC Executive Committee and the two Advisory Committees (Internal and External) establishes and implements program objectives and Core utilization targets, reviews and approves membership applications, organizes the research base into coherent interest groups and facilitates communication among them, oversees program enrichment activities, and administers the P&F and enrichment programs. The Core is responsible for allocation of resources among different Cores based on workflows, user base, technical, and strategic considerations. It is also responsible for administrative oversight of personnel actions, financial management and reporting, conforming to University standards for space and resource utilization, and providing appropriate human resource management to Core Directors to implement billing and expedite technical support and personnel actions. The Core is also responsible for development, maintenance, and timely update of the DRC website. The Core ensures continuity of operations in the event of replacement of Core leadership or technical personnel, and oversees compliance with University regulations regarding human subjects, animal experimentation, technology transfer, hazardous and radioactive maternal compliance. The Administrative Core leadership represents the DRC within the faculty of the College of Physician &Surgeons, and is responsible to ensure that the DRC figures prominently in the school's strategic and programmatic goals. Dr. Domenico Accili, MD will serve as Director of the Administrative Core. In this capacity, he will oversee DRC activities, including DRC membership, administration of Core Facilities and P&F program, convene the Advisory Boards and attend ready meetings of the DRC Pis. He will be assisted by Dr. Rudolph Leibel, DRC Co-PI, Director of Core A (Genomics), and Associate Director for Pilot &Feasibility Program. Together, the Co-PIs will integrate DRC activities with institutional Centers and initiatives that can benefit diabetes research and training. They will ensure the seamless operation of DRC Core facilities and their integration with University-wide facilities (including the NY Obesity Research Center) to avoid duplication of costs and effort. In a similar vein, the Co-PIs will proactively integrate DRC activities with those of other DRCs, especially the neighboring Northeast Centers, as well as other NIDDK consortial and program activities, e.g.. Mouse Metabolic Phenotyping Centers and Beta Cell Biology Consortium.

Public Health Relevance

The Administrative Core is essential to develop the strategy of the Columbia DRC and implement its interdependent elements. It provides overall structural and organizational leadership, it ensures the proper oversight of financial and program enrichment tools, including Core Facilities, and it enables appropriate external review and oversight It integrates different elements of the program to ensure more rapid and efficient access of diabetes researchers to needed resources, encouraging collaborations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK063608-11
Application #
8441342
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Project Start
Project End
Budget Start
2013-03-15
Budget End
2014-01-31
Support Year
11
Fiscal Year
2013
Total Cost
$276,826
Indirect Cost
$85,060
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Ghorpade, Devram S; Ozcan, Lale; Zheng, Ze et al. (2018) Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. Nature 555:673-677
Connors, Thomas J; Baird, J Scott; Yopes, Margot C et al. (2018) Developmental Regulation of Effector and Resident Memory T Cell Generation during Pediatric Viral Respiratory Tract Infection. J Immunol 201:432-439
Savage, Thomas M; Shonts, Brittany A; Obradovic, Aleksandar et al. (2018) Early expansion of donor-specific Tregs in tolerant kidney transplant recipients. JCI Insight 3:
Molusky, Matthew M; Hsieh, Joanne; Lee, Samuel X et al. (2018) Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences. Arterioscler Thromb Vasc Biol 38:1493-1503
Carpenter, D J; Granot, T; Matsuoka, N et al. (2018) Human immunology studies using organ donors: Impact of clinical variations on immune parameters in tissues and circulation. Am J Transplant 18:74-88
Langlet, Fanny; Tarbier, Marcel; Haeusler, Rebecca A et al. (2018) microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function. Mol Metab 17:49-60
Proto, Jonathan D; Doran, Amanda C; Gusarova, Galina et al. (2018) Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity 49:666-677.e6
Carli, Jayne F Martin; LeDuc, Charles A; Zhang, Yiying et al. (2018) The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function. FASEB J 32:3946-3956
Postigo-Fernandez, Jorge; Creusot, RĂ©mi J (2018) A multi-epitope DNA vaccine enables a broad engagement of diabetogenic T cells for tolerance in Type 1 diabetes. J Autoimmun :
Proto, Jonathan D; Doran, Amanda C; Subramanian, Manikandan et al. (2018) Hypercholesterolemia induces T cell expansion in humanized immune mice. J Clin Invest 128:2370-2375

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