The University of California at San Francisco Diabetes Center, an organized research unit, has functioned for more than a half-century as a basic and clinical research enterprise at the forefront of diabetes research. Historically, the program has participated in seminar series, supported early stage research, and emphasized a strong basic and clinical research interface. The goal of the Center is to support a highly interactive team investigating Type 1 and Type 2 diabetes to advance the study and treatment of the disease. The Center encompasses a broad range of intellectual and research expertise from 21 departments and organized research units and four UCSF campuses focused on both basic and clinical research. In this application, the UCSF Diabetes Center proposes to renew its Diabetes and Endocrinology Research Center (DERC) grant funding that supports the following activities: An Administrative Core that provides leadership, infrastructure, administrative support, and advice and oversight to the other components and members of the DERC, and interfaces with the NIDDK, other NIH Diabetes Centers, and the lay community. Biomedical Medical Research Cores Islet Metabolism Core Cytometry and Cell Sorting Core Microscopy Core Mouse Genetics Core A Pilot &Feasibility Program that funds small innovative projects that support new investigators, explore novel areas of investigators for established investigators, attract new investigators to the DERC, promote interactions and lead to external support to further the goals of the DERC. An Enrichment Program that furthers the goals of the DERC by enhancing scientific exchange and training with seminar series, invited speakers and an annual retreat.

Public Health Relevance

The support requested in this application will provide the infrastructure, core laboratories, pilot and feasibility grants, and enrichment programs that will accentuate the collaboration and accelerate the progress of 56 principal investigators at UCSF and their associated groups studying diabetes with the goal of advancing the study and treatment of Type 1 and Type 2 diabetes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK063720-06A1
Application #
7896058
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (J2))
Program Officer
Hyde, James F
Project Start
2002-09-01
Project End
2015-03-31
Budget Start
2010-05-01
Budget End
2011-03-31
Support Year
6
Fiscal Year
2010
Total Cost
$1,313,250
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Puri, Sapna; Roy, Nilotpal; Russ, Holger A et al. (2018) Replication confers ? cell immaturity. Nat Commun 9:485
Corbit, Kevin C; Camporez, João Paulo G; Edmunds, Lia R et al. (2018) Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes 67:208-221
Mocciaro, Annamaria; Roth, Theodore L; Bennett, Hayley M et al. (2018) Light-activated cell identification and sorting (LACIS) for selection of edited clones on a nanofluidic device. Commun Biol 1:41
Miranda, Diego A; Krause, William C; Cazenave-Gassiot, Amaury et al. (2018) LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity. JCI Insight 3:
Greenstein, R A; Jones, Stephen K; Spivey, Eric C et al. (2018) Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability. Elife 7:
Chamberlain, Chester E; German, Michael S; Yang, Katherine et al. (2018) A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors. Mol Cancer Ther 17:2702-2709
Lee, Jessica; Pappalardo, Zachary; Chopra, Deeksha Gambhir et al. (2018) A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Endocrinology 159:3321-3330
Sneddon, Julie B; Tang, Qizhi; Stock, Peter et al. (2018) Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges. Cell Stem Cell 22:810-823
Siljee, Jacqueline E; Wang, Yi; Bernard, Adelaide A et al. (2018) Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Nat Genet 50:180-185
Hennings, Thomas G; Chopra, Deeksha G; DeLeon, Elizabeth R et al. (2018) In Vivo Deletion of ?-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption. Endocrinology 159:3245-3256

Showing the most recent 10 out of 531 publications