Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK072442-04
Application #
7687411
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
4
Fiscal Year
2008
Total Cost
$168,746
Indirect Cost
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Zou, Siying; Teixeira, Alexandra M; Kostadima, Myrto et al. (2017) SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume. PLoS One 12:e0178095
Zou, Siying; Teixeira, Alexandra M; Yin, Mingzhu et al. (2016) Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation. Thromb Haemost 116:506-16
Chin, Joanna Y; Reza, Faisal; Glazer, Peter M (2013) Triplex-forming peptide nucleic acids induce heritable elevations in gamma-globin expression in hematopoietic progenitor cells. Mol Ther 21:580-7
Megyola, Cynthia M; Gao, Yuan; Teixeira, Alexandra M et al. (2013) Dynamic migration and cell-cell interactions of early reprogramming revealed by high-resolution time-lapse imaging. Stem Cells 31:895-905
Kassmer, Susannah H; Krause, Diane S (2013) Very small embryonic-like cells: biology and function of these potential endogenous pluripotent stem cells in adult tissues. Mol Reprod Dev 80:677-90
Kassmer, Susannah H; Jin, Huiyan; Zhang, Ping-Xia et al. (2013) Very small embryonic-like stem cells from the murine bone marrow differentiate into epithelial cells of the lung. Stem Cells 31:2759-66
Smith, Elenoe C; Teixeira, Alexandra M; Chen, Rachel C et al. (2013) Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation. Blood 121:1094-101
Rogers, Faye A; Lin, Sharon S; Hegan, Denise C et al. (2012) Targeted gene modification of hematopoietic progenitor cells in mice following systemic administration of a PNA-peptide conjugate. Mol Ther 20:109-18
Smith, Elenoe C; Thon, Jonathan N; Devine, Matthew T et al. (2012) MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation. Blood 120:2317-29
Gao, Yuan; Smith, Elenoe; Ker, Elmer et al. (2012) Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes. Dev Cell 22:573-84

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