Abstract

The Human Phenotyping Core builds upon a strong research base in the clinical sciences encompassing a wide range of research techniques. The existing tools will be used to explore new avenues of multi-disciplinary clinical research in the area of Nutritional Programming. New data provides substantial evidence that the most common chronic diseases in the United States may have their origins in the regulation of gene expression and functioning vis-a-vis epigenomic regulation. Now, more than ever, the precise quantification of specific clinical phenotypes is essential for the application of genomic technologies and basic science discoveries to the human condition. Also, multi-disciplinary teams are needed to investigate complex, integrated biological phenomena. This Core will integrate established techniques with cutting edge measurements of in-situ biochemistry, ingestive behavior and physical activity to foster research in the area of nutritional programming.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK072476-04
Application #
7669115
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
4
Fiscal Year
2008
Total Cost
$408,538
Indirect Cost

  Institution

Name
Lsu Pennington Biomedical Research Center
Department
Type
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808

  Publications

Sarzynski, Mark A; Ruiz-Ramie, Jonathan J; Barber, Jacob L et al. (2018) Effects of Increasing Exercise Intensity and Dose on Multiple Measures of HDL (High-Density Lipoprotein) Function. Arterioscler Thromb Vasc Biol 38:943-952
Peaceman, Alan M; Clifton, Rebecca G; Phelan, Suzanne et al. (2018) Lifestyle Interventions Limit Gestational Weight Gain in Women with Overweight or Obesity: LIFE-Moms Prospective Meta-Analysis. Obesity (Silver Spring) 26:1396-1404
Yu, Sangho; François, Marie; Huesing, Clara et al. (2018) The Hypothalamic Preoptic Area and Body Weight Control. Neuroendocrinology 106:187-194
Burke, Susan J; Batdorf, Heidi M; Martin, Thomas M et al. (2018) Liquid Sucrose Consumption Promotes Obesity and Impairs Glucose Tolerance Without Altering Circulating Insulin Levels. Obesity (Silver Spring) 26:1188-1196
Herion, Nils Janis; Kruger, Claudia; Staszkiewicz, Jaroslaw et al. (2018) Embryonic cell migratory capacity is impaired upon exposure to glucose in vivo and in vitro. Birth Defects Res :
Katzmarzyk, Peter T; Most, Jasper; Redman, Leanne M et al. (2018) Energy expenditure and substrate oxidation in White and African American young adults without obesity. Eur J Clin Nutr 72:920-922
Hsueh, Wen-Chi; Bennett, Peter H; Esparza-Romero, Julian et al. (2018) Analysis of type 2 diabetes and obesity genetic variants in Mexican Pima Indians: Marked allelic differentiation among Amerindians at HLA. Ann Hum Genet 82:287-299
Yu, Yongmei; Mendoza, Tamra M; Ribnicky, David M et al. (2018) An Extract of Russian Tarragon Prevents Obesity-Related Ectopic Lipid Accumulation. Mol Nutr Food Res 62:e1700856
Yan, Hao; Carmichael, Owen; Paul, Debashis et al. (2018) Estimating fiber orientation distribution from diffusion MRI with spherical needlets. Med Image Anal 46:57-72
Obanda, Diana; Page, Ryan; Guice, Justin et al. (2018) CD Obesity-Prone Rats, but not Obesity-Resistant Rats, Robustly Ferment Resistant Starch Without Increased Weight or Fat Accretion. Obesity (Silver Spring) 26:570-577

Showing the most recent 10 out of 759 publications