Abstract

The Human Phenotyping Core builds upon a strong research base in the clinical sciences encompassing a wide range of research techniques. The existing tools will be used to explore new avenues of multi-disciplinary clinical research in the area of Nutritional Programming. New data provides substantial evidence that the most common chronic diseases in the United States may have their origins in the regulation of gene expression and functioning vis-a-vis epigenomic regulation. Now, more than ever, the precise quantification of specific clinical phenotypes is essential for the application of genomic technologies and basic science discoveries to the human condition. Also, multi-disciplinary teams are needed to investigate complex, integrated biological phenomena. This Core will integrate established techniques with cutting edge measurements of in-situ biochemistry, ingestive behavior and physical activity to foster research in the area of nutritional programming.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK072476-04
Application #
7669115
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
4
Fiscal Year
2008
Total Cost
$408,538
Indirect Cost

  Institution

Name
Lsu Pennington Biomedical Research Center
Department
Type
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808

  Publications

Thomas-Porch, Caasy; Li, Jie; Zanata, Fabiana et al. (2018) Comparative proteomic analyses of human adipose extracellular matrices decellularized using alternative procedures. J Biomed Mater Res A 106:2481-2493
Stephens, Jacqueline M; Bailey, Jennifer L; Hang, Hardy et al. (2018) Adipose Tissue Dysfunction Occurs Independently of Obesity in Adipocyte-Specific Oncostatin Receptor Knockout Mice. Obesity (Silver Spring) 26:1439-1447
Forney, Laura A; Stone, Kirsten P; Wanders, Desiree et al. (2018) Sensing and signaling mechanisms linking dietary methionine restriction to the behavioral and physiological components of the response. Front Neuroendocrinol 51:36-45
Able, Ashley Ann; Richard, Allison J; Stephens, Jm (2018) Loss of DBC1 (CCAR2) affects TNF?-induced lipolysis and Glut4 gene expression in murine adipocytes. J Mol Endocrinol 61:195-205
Most, Jasper; Vallo, Porsha M; Gilmore, L Anne et al. (2018) Energy Expenditure in Pregnant Women with Obesity Does Not Support Energy Intake Recommendations. Obesity (Silver Spring) 26:992-999
Costford, Sheila R; Brouwers, Bram; Hopf, Meghan E et al. (2018) Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance. Mol Metab 7:1-11
Chang, Ji Suk; Ghosh, Sujoy; Newman, Susan et al. (2018) A map of the PGC-1?- and NT-PGC-1?-regulated transcriptional network in brown adipose tissue. Sci Rep 8:7876
Staiano, Amanda E; Martin, Corby K; Champagne, Catherine M et al. (2018) Sedentary time, physical activity, and adiposity in a longitudinal cohort of nonobese young adults. Am J Clin Nutr 108:946-952
Sutton, Elizabeth F; Beyl, Robbie; Early, Kate S et al. (2018) Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metab 27:1212-1221.e3
Fernández-Verdejo, Rodrigo; Bajpeyi, Sudip; Ravussin, Eric et al. (2018) Metabolic flexibility to lipid availability during exercise is enhanced in individuals with high insulin sensitivity. Am J Physiol Endocrinol Metab 315:E715-E722

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