Abstract

The Human Phenotyping Core builds upon a strong research base in the clinical sciences encompassing a wide range of research techniques. The existing tools will be used to explore new avenues of multi-disciplinary clinical research in the area of Nutritional Programming. New data provides substantial evidence that the most common chronic diseases in the United States may have their origins in the regulation of gene expression and functioning vis-a-vis epigenomic regulation. Now, more than ever, the precise quantification of specific clinical phenotypes is essential for the application of genomic technologies and basic science discoveries to the human condition. Also, multi-disciplinary teams are needed to investigate complex, integrated biological phenomena. This Core will integrate established techniques with cutting edge measurements of in-situ biochemistry, ingestive behavior and physical activity to foster research in the area of nutritional programming.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK072476-05
Application #
7918063
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
5
Fiscal Year
2009
Total Cost
$378,569
Indirect Cost

  Institution

Name
Lsu Pennington Biomedical Research Center
Department
Type
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808

  Publications

Kruger, Claudia; Burke, Susan J; Collier, J Jason et al. (2018) Lipid peroxidation regulates podocyte migration and cytoskeletal structure through redox sensitive RhoA signaling. Redox Biol 16:248-254
Boudreau, Anik; Fuller, Scott; Ribnicky, David M et al. (2018) Groundsel Bush (Baccharis halimifolia) Extract Promotes Adipocyte Differentiation In Vitro and Increases Adiponectin Expression in Mature Adipocytes. Biology (Basel) 7:
Losso, Jack N; Finley, John W; Karki, Namrata et al. (2018) Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms. Am J Ther 25:e194-e201
Chang, Ji Suk; Ha, Kyoungsoo (2018) A truncated PPAR gamma 2 localizes to mitochondria and regulates mitochondrial respiration in brown adipocytes. PLoS One 13:e0195007
Nicklas, Theresa; Islam, Noemi G; Saab, Rabab et al. (2018) Validity of a Digital Diet Estimation Method for Use with Preschool Children. J Acad Nutr Diet 118:252-260
Redman, Leanne M; Smith, Steven R; Burton, Jeffrey H et al. (2018) Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging. Cell Metab 27:805-815.e4
Roe, Brian E; Apolzan, John W; Qi, Danyi et al. (2018) Plate waste of adults in the United States measured in free-living conditions. PLoS One 13:e0191813
King, Jill L; Fearnbach, S Nicole; Ramakrishnapillai, Sreekrishna et al. (2018) Perceptual Characterization of the Macronutrient Picture System (MaPS) for Food Image fMRI. Front Psychol 9:17
Bruce-Keller, Annadora J; Salbaum, J Michael; Berthoud, Hans-Rudolf (2018) Harnessing Gut Microbes for Mental Health: Getting From Here to There. Biol Psychiatry 83:214-223
Yu, Sangho; Münzberg, Heike (2018) Testing Effects of Chronic Chemogenetic Neuronal Stimulation on Energy Balance by Indirect Calorimetry. Bio Protoc 8:

Showing the most recent 10 out of 759 publications