Nutrigenomics is a rapidly emerging field that studies the interface between nutrients and genomics. The study of nutrigenomics attempts to relate the processes affecting nutrient metabolism to particular genes or alternatively, to identify specific genes associated with a nutrition-related endpoint and then assess how its relation to nutrient metabolism. Insights derived from nutrigenomics will form the basis of individualized approaches to nutrition, or 'personalized nutrition.' The purpose of the Molecular Genetics and Nutrigenomics (MGN) Core is to provide services and support for basic science and clinical investigators that will enhance our understanding of the molecular and genetic basis of nutrient metabolism and the risk of chronic disease during aging. Elucidation of the genetic underpinnings of nutrition-related diseases and traits may provide key mechanistic insights that may lead to more effective prevention and treatment for these common diseases. To achieve these goals, the MGN Core will provide services to members of the Mid-Atlantic NORC in molecular genetics, genomics, and genetic epidemiology. Additionally, the Core will provide instruction and technical support to NORC users. The services to be provided by the MGN Core wil be in the areas of: (1) molecular genetics (DNA extraction, genotyping, sequencing, mutation detection);(2) molecular genomics (high through SNP genotyping and data processing);(3) and genetic epidemiology (study design, power calcuations, analysis for linkage and association studies, bioinformatics support for GWAS studies, and data mining). The MGN Core was designed to complement services available in other Cores by providing expertise and support to Center investigators to carry out genetic and genomic studies of obesity and other nutrition-related chronic diseases that can be translated into clinical studies to assess gene by environment interactions with support from the CTR Core, and pursued through basic mechanism studies to assess molecular and cellular level mechanisms with support from the ABBM Core. The extensive use and productivity of the MGN Core in the last five years demonstrates the enrichment it provides to ongoing studies by providing Center investigators with ready access to a wide range of services, promoting cross-disciplinary interactions among Center investigators, and educating students, fellows and junior faculty.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK072488-10
Application #
8733157
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
10
Fiscal Year
2014
Total Cost
$233,074
Indirect Cost
$64,632
Name
University of Maryland Baltimore
Department
Type
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Ryan, Alice S; Serra, Monica C; Goldberg, Andrew P (2018) Metabolic Benefits of Prior Weight Loss with and without Exercise on Subsequent 6-Month Weight Regain. Obesity (Silver Spring) 26:37-44
Mitchell, Braxton D; Kalra, Gurmannat; Ryan, Kathleen A et al. (2018) Increased usual physical activity is associated with a blunting of the triglyceride response to a high-fat meal. J Clin Lipidol :
Differding, Moira K; Mueller, Noel T (2018) Are household disinfectants microbially mediated obesogens? CMAJ 190:E1095-E1096
Blau, Jenny E; Taylor, Simeon I (2018) Adverse effects of SGLT2 inhibitors on bone health. Nat Rev Nephrol 14:473-474
Serra, Monica C; Ryan, Alice S; Ortmeyer, Heidi K et al. (2018) Resistance training reduces inflammation and fatigue and improves physical function in older breast cancer survivors. Menopause 25:211-216
Oates, Connor P; Koenig, Darya; Rhyne, Jeffrey et al. (2018) Novel polymorphisms associated with hyperalphalipoproteinemia and apparent cardioprotection. J Clin Lipidol 12:110-115
Suri, Pradeep; Palmer, Melody R; Tsepilov, Yakov A et al. (2018) Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain. PLoS Genet 14:e1007601
Pham, Luu V; Schwartz, Alan R; Jun, Jonathan C (2018) Oxyhemoglobin Saturation Overshoot Following Obstructive Breathing Events Mitigates Sleep Apnea-Induced Glucose Elevations. Front Endocrinol (Lausanne) 9:477
Dugas, Michelle; Crowley, Kenyon; Gao, Guodong Gordon et al. (2018) Individual differences in regulatory mode moderate the effectiveness of a pilot mHealth trial for diabetes management among older veterans. PLoS One 13:e0192807
Rao, Xiaoquan; Deiuliis, Jeffrey A; Mihai, Georgeta et al. (2018) Monocyte DPP4 Expression in Human Atherosclerosis Is Associated With Obesity and Dyslipidemia. Diabetes Care 41:e1-e3

Showing the most recent 10 out of 488 publications