The Administrative Core of the UCSF P30 Cystic Fibrosis (CF) Research and Translation Center provides the central organizational infrastructure for Center studies. Drs. Alan Verkman and Peter Haggie will serve as co- Program Directors, and will be responsible for overall Center organization and scientific direction. The focus of the Center remains the discovery, evaluation and advancement of novel small-molecule CF therapies. The objectives of the Center are achieved by coordinating the efforts of four scientific Cores that provide expertise for small molecule discovery and development. The Cores - High-throughput Screening (Core A), Assays & Cell Models (Core B), Chemistry (Core C), and Animal Pharmacology & Models (Core D) - are directed by accomplished CF investigators who have a history of collaboration. Projects that use the Cores are in three areas: (i) CFTR modulators, (ii) Non-CF Ion Transporter Drug Targets, and (iii) Translational Research: CF Therapeutic Strategies and Targets. The Administrative Core also oversees the Pilot & Feasibility Program of the Center; including project and investigator recruitment, project evaluation, and enabling use of Core facilities. In addition, the Administrative Core organizes Internal and External Advisory Committees for evaluation of Center scientific progress, and organizes enrichment activities, including research conferences, fellow / student training, and journal clubs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK072517-16
Application #
10001905
Study Section
Special Emphasis Panel (ZDK1)
Project Start
2005-08-01
Project End
2023-05-31
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
16
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Sun, Dingyuan I; Tasca, Alexia; Haas, Maximilian et al. (2018) Na+/H+ Exchangers Are Required for the Development and Function of Vertebrate Mucociliary Epithelia. Cells Tissues Organs :1-14
Bhakta, Nirav R; Christenson, Stephanie A; Nerella, Srilaxmi et al. (2018) IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma. Am J Respir Crit Care Med 197:313-324
Smith, Alex J; Verkman, Alan S (2018) The ""glymphatic"" mechanism for solute clearance in Alzheimer's disease: game changer or unproven speculation? FASEB J 32:543-551
Duan, Tianjiao; Smith, Alex J; Verkman, Alan S (2018) Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica. J Neuroinflammation 15:294
Lee, Sujin; Cil, Onur; Diez-Cecilia, Elena et al. (2018) Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1. J Med Chem 61:3209-3217
Tradtrantip, Lukmanee; Felix, Christian M; Spirig, Rolf et al. (2018) Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica. Neuropharmacology 133:345-353
Phuan, Puay-Wah; Veit, Guido; Tan, Joseph-Anthony et al. (2018) ?F508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter. SLAS Discov 23:823-831
Verkman, Alan S; Yao, Xiaoming; Smith, Alex J (2018) The evolving mystery of why skeletal muscle is spared in seropositive neuromyelitis optica. J Cell Mol Med 22:2039-2040
Verkman, Alan S; Smith, Alex J; Phuan, Puay-Wah et al. (2017) The aquaporin-4 water channel as a potential drug target in neurological disorders. Expert Opin Ther Targets 21:1161-1170
Zhu, Jie S; Son, Jung-Ho; Teuthorn, Andrew P et al. (2017) Diverting Reactive Intermediates Toward Unusual Chemistry: Unexpected Anthranil Products from Davis-Beirut Reaction. J Org Chem 82:10875-10882

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