The critical role of the kidney in maintaining fluid and electrolyte balance, and the disorders of homeostasis that are accompany diseases of the kidney and associated loss of renal function underscore the importance of this organ. Our increasing ability to both identify and modify the gene products that are responsible for maintaining normal homeostatic balance offers new and powerful approaches to examine the contributions of individual proteins to the maintenance of normal renal function and the consequences of loss of renal function. The objective of the Pittsburgh Center for Kidney Research is to both reinforce and expand interactions among investigators at the University of Pittsburgh and colleagues at Mount Sinai School of Medicine who have had a longstanding history of research in areas related to the identification and characterization of cellular processes within the kidney that are associated with normal physiology and with path physiological states, to develop new directions of investigation using electrophysiological, cell biological, molecular, and genetic tools, and to attract new investigators to renal-related research. The Center will be focused on four main cores, which will support the work of investigators at the University of Pittsburgh and Mount Sinai School of Medicine. Core A is a cellular physiology core, led by Dr. Hallows. Core B is a single nephron and metabolomics core, led by Drs. Jackson and Satlin. Core C is a kidney imaging core, led by Dr. Apodaca. Core D will focus on the use of model organisms and is led by Drs. Brodsky and Hukriede. The Center will support four pilot and feasibility projects. An administrative core, led by Drs. Kleyman and Weisz, will provide administrative oversight of the core facilities, the pilot and feasibility project program and the educational activities of the center. All research cores are specifically structured to serve as nation-wide resources for investigators. Our Center is designed to realize our goal of continuing to advance our understanding of normal renal function, of cellular mechanisms that contribute to kidney disease, and of the myriad of altered cellular functions that occur in the setting of renal insufficiency.

Public Health Relevance

The goals of the Pittsburgh Center for Kidney Research are to develop and facilitate multidisciplinary research, training and information transfer related to kidney physiology, cell biology, pharmacology and pathophysiology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
3P30DK079307-09S1
Application #
9331974
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (M2)P)
Program Officer
Kimmel, Paul
Project Start
2007-07-01
Project End
2018-07-31
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
9
Fiscal Year
2016
Total Cost
$28,901
Indirect Cost
$2,141
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Sanders, Alison P; Saland, Jeffrey M; Wright, Robert O et al. (2018) Perinatal and childhood exposure to environmental chemicals and blood pressure in children: a review of literature 2007-2017. Pediatr Res 84:165-180
Doonan, Lynley M; Fisher, Edward A; Brodsky, Jeffrey L (2018) Can modulators of apolipoproteinB biogenesis serve as an alternate target for cholesterol-lowering drugs? Biochim Biophys Acta Mol Cell Biol Lipids 1863:762-771
Blobner, Brandon M; Wang, Xue-Ping; Kashlan, Ossama B (2018) Conserved cysteines in the finger domain of the epithelial Na+ channel ? and ? subunits are proximal to the dynamic finger-thumb domain interface. J Biol Chem 293:4928-4939
Kullmann, F Aura; McDonnell, Bronagh M; Wolf-Johnston, Amanda S et al. (2018) Inflammation and Tissue Remodeling in the Bladder and Urethra in Feline Interstitial Cystitis. Front Syst Neurosci 12:13
Sheng, Shaohu; Chen, Jingxin; Mukherjee, Anindit et al. (2018) Thumb domains of the three epithelial Na+ channel subunits have distinct functions. J Biol Chem 293:17582-17592
Hughes, Andrew D; Lakkis, Fadi G; Oberbarnscheidt, Martin H (2018) Four-Dimensional Imaging of T Cells in Kidney Transplant Rejection. J Am Soc Nephrol 29:1596-1600
Theodoraki, M-N; Hoffmann, T K; Jackson, E K et al. (2018) Exosomes in HNSCC plasma as surrogate markers of tumour progression and immune competence. Clin Exp Immunol 194:67-78
Apodaca, Gerard (2018) Role of Polarity Proteins in the Generation and Organization of Apical Surface Protrusions. Cold Spring Harb Perspect Biol 10:
Jackson, Travis C; Kotermanski, Shawn E; Kochanek, Patrick M et al. (2018) Oxidative Stress Induces Release of 2'-AMP from Microglia. Brain Res :
Balchak, Deidra M; Thompson, Rebecca N; Kashlan, Ossama B (2018) The epithelial Na+ channel ? subunit autoinhibitory tract suppresses channel activity by binding the ? subunit's finger-thumb domain interface. J Biol Chem 293:16217-16225

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