The critical role of the kidney in maintaining homeostatic balance, and the disorders of homeostasis that accompany diseases of the kidney and the associated loss of kidney function underscore the importance of this organ in human health. Recent developments in biomedical sciences have led to significant advancements in our understanding of the pathogenesis of specific renal diseases, which have important diagnostic and therapeutic implications.
The Aim of our Pittsburgh Center for Kidney Research is to develop and facilitate multidisciplinary research, training and information transfer related to kidney function in normal and disease states. The major goals of our center are (i) to advance our knowledge base regarding normal kidney function, cellular mechanisms that contribute to kidney disease and the many altered cellular functions that occur in the settings of acute kidney injury and chronic kidney disease; (ii) to facilitate early-phase translational investigation, including studies using animal models, studies directed at drug discovery, development and pharmacokinetics, as well as support for analytical studies; and (iii) to provide the expertise, training and equipment needed to facilitate research activities in these areas. Center Core facilities support the work of one hundred and eleven investigators at the University of Pittsburgh, the Icahn School of Medicine at Mount Sinai, and at other institutions throughout the United States. Core A is a Physiology Core, led by Drs. Carattino and Satlin. Core B is an Animal and Translational Core, led by Drs. Jackson and Stocker. Core C is a Kidney Imaging Core, led by Dr. Apodaca. Core D is a Model Systems and Therapeutics Core, led by Drs. Brodsky and Hukriede. The Center supports four pilot and feasibility projects. An Administrative Core, led by Drs. Kleyman and Weisz, provides administrative oversight of the core facilities, the pilot and feasibility project program and the educational activities of the center. All research cores are specifically structured to serve as national resources for investigators. Our Center is designed to realize our goal of continuing to advance our understanding of normal renal function, of cellular mechanisms that contribute to kidney disease, and of the many altered cellular functions that occur in the settings of acute kidney injury and chronic kidney disease.

Public Health Relevance

The goals of the Pittsburgh Center for Kidney Research are to develop and facilitate multidisciplinary research, training and information transfer related to kidney function in normal and disease states. To achieve these goals, the center supports four core facilities, four pilot and feasibility projects, and a series of educational programs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK079307-12
Application #
9752512
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Kimmel, Paul
Project Start
2008-09-01
Project End
2023-07-31
Budget Start
2019-08-01
Budget End
2020-07-31
Support Year
12
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15260
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Theodoraki, M-N; Hoffmann, T K; Jackson, E K et al. (2018) Exosomes in HNSCC plasma as surrogate markers of tumour progression and immune competence. Clin Exp Immunol 194:67-78
Apodaca, Gerard (2018) Role of Polarity Proteins in the Generation and Organization of Apical Surface Protrusions. Cold Spring Harb Perspect Biol 10:

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